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A Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily with a Wide Tissue Distribution and Involvement in Lymphocyte Activation
DC Field | Value | Language |
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dc.contributor.author | Kwon, Byoung S. | - |
dc.contributor.author | Tan, Kong B. | - |
dc.contributor.author | Ni, Jian | - |
dc.contributor.author | Oh, Kwi-Ok | - |
dc.contributor.author | Lee, Zang H | - |
dc.contributor.author | Kim, Kack K. | - |
dc.contributor.author | Kim, Young-J | - |
dc.contributor.author | Wang, Sa | - |
dc.contributor.author | Gentz, Reiner | - |
dc.contributor.author | Yu, Guo-Liang | - |
dc.contributor.author | Harrop, Jeremy | - |
dc.contributor.author | Lyn, Sally D. | - |
dc.contributor.author | Silverman, Carol | - |
dc.contributor.author | Porter, Terence G. | - |
dc.contributor.author | Truneh, Alem | - |
dc.contributor.author | Young, Peter R. | - |
dc.date.accessioned | 2011-10-18T07:15:23Z | - |
dc.date.available | 2011-10-18T07:15:23Z | - |
dc.date.issued | 1997-05 | - |
dc.identifier.citation | J. Bio. Chem. 272,14272-14276 | en |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74287 | - |
dc.description.abstract | The tumor necrosis factor receptor (TNFR) superfamily
consists of approximately 10 characterized members of human proteins. We have identified a new member of the TNFR superfamily, TR2, from a search of an expressed sequence tag data base. cDNA cloning and Northern blot hybridization demonstrated multiple mRNA species, of which a 1.7-kilobase form was most abundant. However, TR2 is encoded by a single gene which, maps to chromosome 1p36.22–36.3, in the same region as several other members of the TNFR superfamily. The most abundant TR2 open reading frame encodes a 283-amino acid single transmembrane protein with a 36-residue signal sequence, two perfect and two imperfect TNFR-like cysteine-rich domains, and a short cytoplasmic tail with some similarity to 4–1BB and CD40. TR2 mRNA is expressed in multiple human tissues and cell lines and shows a constitutive and relatively high expression in peripheral blood T cells, B cells, and monocytes. A TR2-Fc fusion protein inhibited a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation. | en |
dc.description.sponsorship | This work was supported by National Institutes of Health Grants AI 28175 and AR 40248 (to B. S. K.) and by a postdoctoral fellowship from the American Heart Association, Indiana Affiliate (to S. W.). | en |
dc.language.iso | en | en |
dc.publisher | American Society for Biochemistry and Molecular Biology | en |
dc.title | A Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily with a Wide Tissue Distribution and Involvement in Lymphocyte Activation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 오귀옥 | - |
dc.contributor.AlternativeAuthor | 이장희 | - |
dc.contributor.AlternativeAuthor | 김각균 | - |
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