Browse

구순구개열 환자의 치아 선천결손 유형과 관련 유전자에 관한 고찰
Hypodontia Pattern and Genetic Association in Cleft Lip and Palate Patients

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors
안효원; 백승학
Issue Date
2007-12
Publisher
대한구순구개열학회
Citation
대한구순구개열학회지 2007;10(2)81-88
Keywords
Cleft lip and palateHypodontiaGenetics
Abstract
Cleft lip and palate (CLP) is one of the most prevalent congenital craniofacial anomalies. It has a significantly greater incidence of dental abnormalities in number, size, shape, and eruption of the teeth. Knout-out mouse model can identify several genes which play an important role in tooth agenesis. Since disruption of these genes has been confirmed to result in tooth agenesis in humans, CLP associated with hypodontia may be the best models for isolated tooth agenesis. According to the studies of dental abnormalities in CLP, the severity of dental defect is known to be influenced by the CLP phenotype. The cumulative data obtained from mouse and human genetic studies indicated that MSX1, PAX9 and AXIN2 are considered as candidate genes in non-syndromic hypodontia, while Shh, Pitx2, Irf6, p63 and EDA pathway genes are involved in syndromic one. We expect that genetic approach of CLP can offer the basis for tooth regeneration and be a new target in hypodontia therapy.
ISSN
1229-0734
Language
Korean
URI
http://hdl.handle.net/10371/74394
Files in This Item:
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse