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Effective mixing in a microfluidic chip using magnetic particles

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Authors
Lee, Seung Hwan; van Noort, Danny; Lee, Ji Youn; Zhang, Byoung-Tak; Park, Tai Hyun
Issue Date
2009
Publisher
Royal Society of Chemistry
Citation
Lab Chip, 2009, 9, 479-482
Keywords
MICROCHANNELSGENERATIONGRADIENTSSYSTEMSSENSORFLOW
Abstract
We present a novel active mixing method in a microfluidic chip, where the controlled stirring of magnetic particles is used to achieve an effective mixing of fluids. To perform mixing, the ferromagnetic particles were embedded and manipulated under the influence of a rotating magnetic field. By aligning the magnetic beads along the magnetic field lines, rod-like structures are formed, functioning as small stir bars. Under higher flow conditions the particles did not form the typical rod structure but rather formed aggregates, which were even more beneficial for mixing. Our system reached a 96% mixing efficiency in a relatively short distance (800 mm) at a flow rate of 1.2-4.8 mm/s. These results demonstrate that our mixing method is useful for microfluidic devices with low aspect ratios and molecules with large molecular weights.
ISSN
1473-0197
Language
English
URI
http://hdl.handle.net/10371/7442
DOI
https://doi.org/10.1039/b814371d
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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