Publications

Detailed Information

Fabrication of patterned micromuscles with high activity for powering biohybrid microdevices

Cited 29 time in Web of Science Cited 33 time in Scopus
Authors

Kim, Deok-Ho; Park, Jungyul; Suh, Kahp Y.; Kim, Pilnam; Choi, Seun Kyu; Ryu, Seokchang; Park, Sukho; Lee, Sang Ho; Kim, Byungkyu

Issue Date
2006-10-12
Publisher
Elsevier
Citation
Sensors and Actuators B 117 (2006) 391-400
Keywords
micropatterningcardiac musclespolyethylene glycol (PEG)capillary lithographybioactuatorbiohybrid microdeviceCARDIAC MYOCYTESCELL-ADHESIONSURFACESFORCEMONOLAYERSMOTORPDMS
Abstract
In this paper, we report a microfabrication approach to patterned three-dimensional growth of muscle cells for powering biohybrid microdevices. The microwells confined by adhesion-resistant polyethylene glycol (PEG) microstructures were patterned on SiO2-based substrate with controllable surface topography for muscle cell culturing. The morphology and motility of neonatal rat cardiac myocytes patterned within microwells were analyzed with different topographical heights of the PEG barrier. It was found that isolated aggregates of cardiac muscles showed various beating activities depending on the morphology and the number of cells. Furthermore, three-dimensionally grown cardiac muscle cells mediated by a higher physical barrier of PEG microstructures generated higher contraction force with faster beating frequency than those of cells attached to the collagen-coated surface on the culture dish (control), suggesting that control over surface topography of microwells for cell growth would be potentially useful in engineering cell motors. Thus the technique presented here would provide a valuable platform for optimizing the activity and functions of patterned muscle cells in building up integrated bioactuated microdevices.
ISSN
0925-4005
Language
English
URI
https://hdl.handle.net/10371/7459
DOI
https://doi.org/10.1016/j.snb.2005.11.051
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share