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Development of Microelectrode Arrays for Artificial Retinal Implants using Liquid Crystal Polymers

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Authors
Lee, Seung Woo; Seo, Jong-Mo; Ha, Seungmin; Kim, Eui Tae; Chung, Hum; Kim, Sung June
Issue Date
2009-06-24
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Citation
Investigative Ophthalmology and Visual Science, published online ahead of print June 24, 2009
Keywords
Liquid crystal polymer (LCP)microelectrode arrayretinal prosthesisblister testoptical coherence tomographyelectrically evoked cortical potentials
Abstract
Purpose: To develop a liquid crystal polymer (LCP) based, long-term implantable, retinal stimulation microelectrode array using a novel fabrication method. Methods: The fabrication process used laser micromachining and customized thermal
press bonding to produce LCP based microelectrode arrays. To evaluate the fabrication process and the resulting electrode arrays, in vitro reliability tests and in vivo animal experiments were performed. The in vitro tests consisted of electrode site impedance recording and electrode inter-layer adhesion monitoring during accelerated soak tests. For in vivo testing, the fabricated electrode arrays were implanted in the suprachoroidal space of rabbit eyes. Optical coherence tomography (OCT) and electrically evoked cortical potentials (EECPs) were used to determine long-term biocompatibility and functionality of the implant.Results: The fabricated structure had a smooth, rounded edge profile and exhibited moderate flexibility, which are advantageous features for safe implantation without guide tools. Following accelerated soak tests at 75°C in phosphate buffered saline, the electrode sites showed no degradation and the inter-layer adhesion of the structure showed acceptable stability for more than 2 months. The electrode arrays were safely implanted in the suprachoroidal space of rabbit eyes, and 1 EECP waveforms were recorded. Over a 3-month postoperative period, no choroioretinal inflammation or structural deformities were observed by OCT and histological examination. Conclusions: LCP based flexible microelectrode arrays can be successfully applied as retinal prostheses. The results demonstrate that such electrode arrays are safe, biocompatible, mechanically stable, and can be effective as part of a chronic retinal implant system.
ISSN
0146-0404
Language
English
URI
http://hdl.handle.net/10371/7461
DOI
https://doi.org/10.1167/iovs.09-3743
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Electrical and Computer Engineering (전기·정보공학부)Journal Papers (저널논문_전기·정보공학부)
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