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Antiobesity effect of trans-10, cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice

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Authors
Lee, K.; Paek, K.; Lee, H.Y.; Park, Jae Hak; Lee, Y.
Issue Date
2007-04-13
Publisher
Wiley-Blackwell;
Society for applied microbiology
Citation
J Appl Microbiol 103, 1140-1146
Keywords
antiobesityconjugated linoleic acidLactobacillus plantarumprobiotictrans-10cis-12-CLA
Abstract
Aims: To observe the antiobesity activity of trans-10, cis-12-conjugated linoleic acid (CLA)-producing lactobacillus in mice. Methods and Results: Lactobacillus plantarum PL62, which can grow in the presence of linoleic acid, was selected and studied. The culture supernatant of Lact. plantarum PL62 contained trans-10, cis-12-conjugated linoleic acid (6·4 μg ml<sup>−1</sup>), and the crude enzyme prepared from washed cells produced trans-10, cis-12 CLA (1395 μg mg<sup>−1</sup> protein). Lact. plantarum PL62 reduced the weights of epididymal, inguinal, mesenteric, and perirenal white adipose tissues and significantly reduced the blood levels of total glucose and body weights of mice ( P < 0·01). Conclusions: trans-10, cis-12-CLA-producing Lact. plantarum PL62 can exert the same antiobesity activity as trans-10, cis-12-CLA in mice. Significance and impact of the study: trans-10, cis-12-CLA-producing Lactobacillus can be a replacement for CLA for obesity treatment via the continuous production of trans-10, cis-12-CLA. The results provide a novel opportunity to develop foods with antiobesity activity.
ISSN
1364-5072
Language
English
URI
http://hdl.handle.net/10371/7463
DOI
https://doi.org/10.1111/j.1365-2672.2007.03336.x
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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