SHERP

Fabrication of nanostructures of polyethylene glycol for applications to protein adsorption and cell adhesion

Cited 0 time in webofscience Cited 134 time in scopus
Authors
Kim, P.; Kim, D. H.; Kim, B.; Choi, S. K.; Lee, S. H.; Khademhosseini, A.; Langer, R.; Suh, K. Y.
Issue Date
2005-10
Publisher
Institute of Physics
Citation
Nanotechnology 16 2420
Keywords
SELF-ASSEMBLED MONOLAYERSSOFT LITHOGRAPHYMAMMALIAN-CELLSMICROSTRUCTURESMOLDSTABILITYSURFACESPATTERNBIOLOGYFILMS
Abstract
A simple method was developed to fabricate polyethylene glycol (PEG) nanostructures using capillary lithography mediated by ultraviolet (UV) exposure. Acrylate-containing PEG monomers, such as PEG dimethacrylate (PEG-DMA, MW = 330), were photo-cross-linked under UV exposure to generate patterned structures. In comparison to unpatterned PEG films, hydrophobicity of PEG nanostructure modified surfaces was significantly enhanced. This could be attributed to trapped air in the nanostructures as supported by water contact angle measurements. Proteins (fibronectin, immunoglobulin, and albumin) and cells (fibroblasts and P19 EC cells) were examined on the modified surfaces to test for the level of protein adsorption and cell adhesion. It was found that proteins and cells preferred to adhere on nanostructured PEG surfaces in comparison to unpatterned PEG films; however, this level of adhesion was significantly lower than that of glass controls. These results suggest that capillary lithography can be used to fabricate PEG nanostructures capable of modifying protein and cell adhesive properties of surfaces.
ISSN
0957-4484
Language
English
URI
http://hdl.handle.net/10371/7510
DOI
https://doi.org/10.1088/0957-4484/16/10/072
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Mechanical Aerospace Engineering (기계항공공학부)Journal Papers (저널논문_기계항공공학부)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse