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Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli
DC Field | Value | Language |
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dc.contributor.author | Kim, Hee Kee | - |
dc.contributor.author | Schattschneiderb, Jörn | - |
dc.contributor.author | Lee, Inhyung | - |
dc.contributor.author | Chung, Kyungsoon | - |
dc.contributor.author | Baron, Ralf | - |
dc.contributor.author | Chung, Jin Mo | - |
dc.date.accessioned | 2009-08-24T08:35:55Z | - |
dc.date.available | 2009-08-24T08:35:55Z | - |
dc.date.issued | 2006-10-28 | - |
dc.identifier.citation | Pain 2007;129:93-101 | en |
dc.identifier.issn | 0304-3959 | - |
dc.identifier.uri | https://hdl.handle.net/10371/7608 | - |
dc.description.abstract | This study tests the hypothesis that central sensitization initiated by nociceptive input can be maintained by repeated brief innocuous peripheral inputs. Capsaicin was injected intradermally into the hind paw of adult rats. Three different types of daily cutaneous mechanical stimulations (vibration, soft brush, or pressure) were applied to the capsaicin-injected paw for a period of 2 weeks. Daily stimulation consisted of a 10-s stimulation repeated every 30 s for 30 min. Foot withdrawal thresholds to von Frey stimuli applied to the paw were measured once a day for 4 weeks. The capsaicin-only group (control rats without daily stimulation) showed hyperalgesia lasting for 3 days. In contrast, hyperalgesia persisted for 2 weeks in the group that received vibration stimulation. Neither the soft brush nor the pressure group showed a significant difference in mechanical threshold from the control group (capsaicin only). The vibration-induced prolonged hyperalgesia was significantly reduced by systemic injection of ifenprodil, an NMDA-receptor antagonist, but it was not influenced by either an AMPA-receptor blocker or a reactive oxygen species (ROS) scavenger. Furthermore, a dorsal column lesion did not interfere with the prolongation of hyperalgesia. Data suggest that vibration-induced prolongation of hyperalgesia is mediated by spinal NMDA-receptors, and a similar mechanism may underlie some forms of chronic pain with no obvious causes, such as complex regional pain syndrome type 1 (CRPS-1). | en |
dc.description.sponsorship | This work was supported by NIH Grants R01 NS31680, AT01474, and P01 NS11255. J.S. was a visiting scholar supported by the Novartis Foundation, and also partially by (1) the Deutsche Forschungsgemeinschaft (DFG Ba 1921/1–3), (2) the German Research Network on Neuropathic Pain of the German Ministry of Research and Education (BMBF, 01EM0/1/04), and (3) an unrestricted educational grant from Pfizer, Germany. We express our gratitude to Ms. Denise Broker for her excellent assistance in editing the manuscript. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Capsaicin | en |
dc.subject | Chronic pain | en |
dc.subject | CRPS-1 | en |
dc.subject | Central sensitization | en |
dc.subject | Hyperalgesia | en |
dc.subject | NMDA-receptor | en |
dc.subject | Persistent pain | en |
dc.subject | Vibration stimulation | en |
dc.title | Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김희기 | - |
dc.contributor.AlternativeAuthor | 이인형 | - |
dc.contributor.AlternativeAuthor | 정경순 | - |
dc.contributor.AlternativeAuthor | 정진모 | - |
dc.identifier.doi | 10.1016/j.pain.2006.09.036 | - |
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