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Kidney Transplantation in Sensitized Recipients; A Single Center Experience

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dc.contributor.authorKim, Sun Moon-
dc.contributor.authorLee, Chungsik-
dc.contributor.authorLee, Jung Pyo-
dc.contributor.authorKim, Eun Man-
dc.contributor.authorKim, Sang Joon-
dc.contributor.authorAhn, Curie-
dc.contributor.authorKim, Yon Su-
dc.contributor.authorPark, Myoung Hee-
dc.contributor.authorHa, Jongwon-
dc.date.accessioned2012-05-22T01:59:37Z-
dc.date.available2012-05-22T01:59:37Z-
dc.date.issued2009-01-
dc.identifier.citationJOURNAL OF KOREAN MEDICAL SCIENCE; Vol.24 ; S143-S147ko_KR
dc.identifier.issn1011-8934-
dc.identifier.urihttp://hdl.handle.net/10371/76201-
dc.description.abstractA successful transplantation, across a positive crossmatch barrier, is one of the most persistent long- standing problems in the field of kidney transplant medicine. The aim of this study was to describe seven consecutive living renal transplantations in recipients with positive crossmatch for donors or positive for donor specific antibodies (DSAs). A preconditioning regimen including plasmapheresis and intravenous immunoglobulin was delivered three times a week until the crossmatch and/or DSAs became negative. Mycophenolate mofetil and tacrolimus were started two days before the plasmapheresis. The protocol was modified to include administration of anti-CD 20 antibody (rituximab, 375 mg/m(2)) from the patient number 3 through the patient number 7. All seven patients achieved negative conversion of the crossmatch or DSAs, and the kidney transplantations were successfully performed in all cases. Acute cellular rejection occurred in two patients, which were subclinical and controlled with high dose steroid treatment. Antibody-mediated rejection occurred in one patient, which was easily reversed with plasmapheresis. All recipients attained normal graft function during the 7-24 months of follow up. Our study suggests that sensitized patients can be transplanted successfully with desensitization pretreatment.ko_KR
dc.language.isoenko_KR
dc.publisherKOREAN ACAD MEDICAL SCIENCESko_KR
dc.subjectDesensitizationko_KR
dc.subjectImmunologicko_KR
dc.subjectRituximabko_KR
dc.subjectPlasmapheresisko_KR
dc.subjectKidney Transplantationko_KR
dc.subjectIntravenousko_KR
dc.subjectImmunoglobulinsko_KR
dc.titleKidney Transplantation in Sensitized Recipients; A Single Center Experienceko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김선문-
dc.contributor.AlternativeAuthor이충식-
dc.contributor.AlternativeAuthor이정표-
dc.contributor.AlternativeAuthor김은만-
dc.contributor.AlternativeAuthor하종원-
dc.contributor.AlternativeAuthor김상준-
dc.contributor.AlternativeAuthor박명희-
dc.contributor.AlternativeAuthor안규리-
dc.contributor.AlternativeAuthor김연수-
dc.identifier.doi10.3346/jkms.2009.24.S1.S143-
dc.citation.journaltitleJOURNAL OF KOREAN MEDICAL SCIENCE-
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dc.description.tc2-
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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