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HIF-2 alpha Enhances beta-Catenin/TCF-Driven Transcription by Interacting with beta-Catenin
DC Field | Value | Language |
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dc.contributor.author | Choi, Hyunsung | - |
dc.contributor.author | Chun, Yang-Sook | - |
dc.contributor.author | Park, Jong-Wan | - |
dc.contributor.author | Kim, Tae-You | - |
dc.date.accessioned | 2012-05-22T02:15:49Z | - |
dc.date.available | 2012-05-22T02:15:49Z | - |
dc.date.issued | 2010-12-15 | - |
dc.identifier.citation | CANCER RESEARCH; Vol.70 24; 10101-10111 | ko_KR |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76206 | - |
dc.description.abstract | The tumor-promoting factors beta-catenin and hypoxia-inducible factor (HIF) are often found to be coactivated in rapidly growing tumors. Recently, it was shown that HIF-1 alpha negatively regulates Wnt/beta-catenin signaling by sequestering beta-catenin from beta-catenin/T-cell factor (TCF). However, no investigation has been undertaken on the involvement of HIF-2 alpha in beta-catenin regulation. In this study, it was found that, like HIF-1 alpha, HIF-2 alpha interacts with beta-catenin, but at a different site. Furthermore, HIF-2 alpha was found to assemble with beta-catenin/TCF and facilitate gene transcription. Mutational analyses revealed that transactivation domains of HIF-2 alpha promote p300 coactivator recruitment by beta-catenin. Furthermore, HIF-2 alpha and beta-catenin were found to associate in the nuclei of 786-0 renal cell carcinoma cells, and HIF-2 alpha was found to be required for beta-catenin activation in these cells and for their proliferation. These results suggest that this interaction contributes to the unrestrained growth of tumor cells containing coactivated HIF-2 alpha and beta-catenin. Interestingly, these actions of HIF-2 alpha oppose those of HIF-1 alpha on beta-catenin and cell growth, and this suggests that HIF-1 alpha/HIF-2 alpha balance may importantly determine cell growth when hypoxia and Wnt stimulation coexist. Cancer Res; 70(24); 10101-11. (C) 2010 AACR. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER ASSOC CANCER RESEARCH | ko_KR |
dc.title | HIF-2 alpha Enhances beta-Catenin/TCF-Driven Transcription by Interacting with beta-Catenin | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 최현성 | - |
dc.contributor.AlternativeAuthor | 김태유 | - |
dc.contributor.AlternativeAuthor | 박종완 | - |
dc.contributor.AlternativeAuthor | 전양숙 | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-10-0505 | - |
dc.citation.journaltitle | CANCER RESEARCH | - |
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dc.description.tc | 3 | - |
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