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Early recombinant human epidermal growth factor treatment recovers the irradiation-induced decrease of Na plus absorption prior to the definite histological mucositis

Cited 3 time in Web of Science Cited 3 time in Scopus
Authors
Kim, Jin Kyoung; Kim, Chung Su; Ahn, Hyun Joo; Yoo, Hae Young; Jeong, Han-Sin; Kim, Sung Joon; Bang, Si Ra
Issue Date
2010-11
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation
BIOMEDICINE & PHARMACOTHERAPY; Vol.64 9; 594-599
Keywords
RadiationEpidermal growth factorIon transportShort circuit currentEpithelium
Abstract
Recombinant human epidermal growth factor (rhEGF) has potential benefit for the mucositis induced by radiation therapy as a therapeutic setting. In this study, we aimed to investigate the effects of rhEGF treatment on the radiation-induced changes in epithelial transport function, before the occurrence of the definitive histological mucosal changes. C3H/He mice received 0, 4, or 8 Gy irradiation and/or EGF treatment (rhEGF 0, 1 and 5 mg/kg, i.p., 5 days). At day 7, we recorded short circuit current (I(sc)) of the upper tracheal epithelium using the flow-type Ussing chamber method, with histological analysis. As a result, there was no evident pathological change in the epithelium from the irradiated and/or rhEGF treated mice at day 7. The initial level of I(sc) and amiloride-sensitive I(sc) (Delta I(sc,Amil)) were decreased after 8 Gy irradiation, reflecting suppression of basal Na(+) absorption. The decreased 6,1,Amil was recovered by rhEGF treatment. In conclusion, epithelial Na(+) channel-dependent basal Na(+) absorption was primarily affected by irradiation, before the pathological changes. The recovery of basal Na(+) absorption (Delta I(sc,Amil)) suggested a potentially beneficial effect of early rhEGF treatment for irradiation-induced suppression of the upper aerodigestive epithelial functions. (C) 2010 Elsevier Masson SAS. All rights reserved.
ISSN
0753-3322
Language
English
URI
http://hdl.handle.net/10371/76210
DOI
https://doi.org/10.1016/j.biopha.2010.06.005
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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