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Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients

Cited 34 time in Web of Science Cited 35 time in Scopus
Authors
Choi, Chang-Min; Seo, Kwang Won; Jang, Se Jin; Oh, Yeon-Mok; Kim, Woo Sung; Lee, Sang-Do; Lee, Dong-Soon; Shim, Tae-Sun
Issue Date
2009-04
Publisher
ELSEVIER IRELAND LTD
Citation
LUNG CANCER; Vol.64 1; 66-70
Keywords
Lung cancerFISHPrognosisChromosomal instabilityAdenocarcinomaSurvival
Abstract
Background: in this study, we Sought to evaluate the prognostic importance of chromosomal instability (CIN) in adenocarcinoma (AC) of the lung. The relationship between CIN detected by fluorescence in situ hybridization (FISH) and survival in AC patients was examined. Methods: Sixty-three Surgical specimens Of lung AC were analyzed. To identify tumors with CIN, p 16 and multi-target DNA FISH assays for c-myc, chromosome 6, EGFR, and chromosome 5 (LAVysion, Vysis) were performed on nuclei extracted from paraffin-embedded tumor tissues. Survival rates were compared in terms of sex, age, histology, T factor, N factor, CIN, and smoking Status. A sample was classified as CIN-positive if at least three of the five chromosomes were positive. Results: Out of the 63 specimens, 32 (39.7%) were CIN-positive. The 5-year overall disease-free survival rate was 58.7% as a whole, 46.9% for CIN-positive patients and 71.0% for the CIN-negative patients I hazard ratio (HR), 2.34: 95% confidence interval (CI), 1.04-5.26; p = 0.04]. The 5-year overall survival rate was 81.0%, 68.7% for CIN-positive patients and 93.5% for the CIN-negative patients (HR, 5.64; 95% CI, 1.23-25.70; p = 0.026). In multivariate analysis after adjusting for pathologic nodal staging, tumor staging, sex, age, and smoking history, compared with the CIN-negative patients, the CIN-positive Status remained significantly associated with decreased overall survival (HR, 8.48: 95% CI, 1.66-43.42; p 0.010). Conclusions: CIN can be effectively detected in primary AC of lung using FISH analysis. CIN is associated with poor Prognosis for AC, and may thus be utilized as an independent Prognostic factor for the disease. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
ISSN
0169-5002
Language
English
URI
http://hdl.handle.net/10371/76234
DOI
https://doi.org/10.1016/j.lungcan.2008.07.016
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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