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Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells

Cited 35 time in Web of Science Cited 46 time in Scopus
Authors
Kim, Su-Hwa; Nam, Joo-Hyun; Kim, Byung Joo; Park, Eun Jung; Kim, Sung Joon; Jeon, Ju-Hong; So, Insuk
Issue Date
2009-01
Publisher
ELSEVIER SCIENCE BV
Citation
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE; Vol.1792 1; 33-38
Keywords
MentholCa(2+)TRPM8Cell deathProstate cancer
Abstract
Menthol, a naturally occurring compound from peppermint oil, binds and activates the TRPM8 Ca(2+)-permeable channel that exhibits abnormal expression patterns in prostate cancer, suggesting that TRPM8 links Ca(2+) transport pathways to tumor biology. We thus investigated the cellular responses of prostate cancer cells to menthol. Here we found that menthol increases [Ca(2+)]; via Ca(2+) influx mechanism(s) independent of TRPM8 in PC-3 cells. We demonstrated that menthol induces cell death at supramillimolar concentrations in PC-3 cells and the cell death is not suppressed by low extracellular Ca(2+) condition which indicates that menthol-induced cell death is not associated with Ca(2+) influx pathways. In addition, we showed that menthol increases a phosphorylated form of c-jun N-terminal kinase (JNK) in PC-3 cells through TRPM8-independent mechanisms. Thus, our data indicate that there is an apparent lack of causality between TRPM8 activation and menthol-induced cell death and that menthol can regulate TRPM8-independent Ca(2+)-transport and cellular processes. (C) 2008 Elsevier B.V. All rights reserved.
ISSN
0925-4439
Language
English
URI
http://hdl.handle.net/10371/76249
DOI
https://doi.org/10.1016/j.bbadis.2008.09.012
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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