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Lysophosphatidylcholine Activates Adipocyte Glucose Uptake and Lowers Blood Glucose Levels in Murine Models of Diabetes

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dc.contributor.authorYea, Kyungmoo-
dc.contributor.authorKim, Jaeyoon-
dc.contributor.authorYoon, Jong Hyuk-
dc.contributor.authorKwon, Taewan-
dc.contributor.authorLee, Byoung Dae-
dc.contributor.authorLee, Seung Jae-
dc.contributor.authorLee, Taehoon G.-
dc.contributor.authorPark, Ho Seon-
dc.contributor.authorOhba, Motoi-
dc.contributor.authorRyu, Sung Ho-
dc.contributor.authorSuh, Pann-Ghill-
dc.contributor.authorPark, Kyong Soo-
dc.contributor.authorBaek, Moon-Chang-
dc.contributor.authorKim, Jong-In-
dc.contributor.authorLee, Hae-Jeong-
dc.contributor.authorKim, Jong Hyun-
dc.date.accessioned2012-05-22T07:55:41Z-
dc.date.available2012-05-22T07:55:41Z-
dc.date.issued2009-12-04-
dc.identifier.citationJOURNAL OF BIOLOGICAL CHEMISTRY; Vol.284 49; 33833-33840ko_KR
dc.identifier.issn0021-9258-
dc.identifier.urihttp://hdl.handle.net/10371/76252-
dc.description.abstractGlucose homeostasis is maintained by the orchestration of peripheral glucose utilization and hepatic glucose production, mainly by insulin. In this study, we found by utilizing a combined parallel chromatography mass profiling approach that lysophosphatidylcholine (LPC) regulates glucose levels. LPC was found to stimulate glucose uptake in 3T3-L1 adipocytes dose- and time-dependently, and this activity was found to be sensitive to variations in acyl chain lengths and to polar head group types in LPC. Treatment with LPC resulted in a significant increase in the level of GLUT4 at the plasma membranes of 3T3-L1 adipocytes. Moreover, LPC did not affect IRS-1 and AKT2 phosphorylations, and LPC-induced glucose uptake was not influenced by pretreatment with the PI 3-kinase inhibitor LY294002. However, glucose uptake stimulation by LPC was abrogated both by rottlerin (a protein kinase C delta inhibitor) and by the adenoviral expression of dominant negative protein kinase C delta. In line with its determined cellular functions, LPC was found to lower blood glucose levels in normal mice. Furthermore, LPC improved blood glucose levels in mouse models of type 1 and 2 diabetes. These results suggest that an understanding of the mode of action of LPC may provide a new perspective of glucose homeostasis.ko_KR
dc.language.isoenko_KR
dc.publisherAMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INCko_KR
dc.titleLysophosphatidylcholine Activates Adipocyte Glucose Uptake and Lowers Blood Glucose Levels in Murine Models of Diabetesko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor예경무-
dc.contributor.AlternativeAuthor김재윤-
dc.contributor.AlternativeAuthor윤종혁-
dc.contributor.AlternativeAuthor권태완-
dc.contributor.AlternativeAuthor김종현-
dc.contributor.AlternativeAuthor이병대-
dc.contributor.AlternativeAuthor이해정-
dc.contributor.AlternativeAuthor이승재-
dc.contributor.AlternativeAuthor김종인-
dc.contributor.AlternativeAuthor이태훈-
dc.contributor.AlternativeAuthor백문창-
dc.contributor.AlternativeAuthor박호선-
dc.contributor.AlternativeAuthor박경수-
dc.contributor.AlternativeAuthor서판길-
dc.contributor.AlternativeAuthor류성호-
dc.identifier.doi10.1074/jbc.M109.024869-
dc.citation.journaltitleJOURNAL OF BIOLOGICAL CHEMISTRY-
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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