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Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract
DC Field | Value | Language |
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dc.contributor.author | Kim, Sang-Eun | - |
dc.contributor.author | Thuy, Tran Thi Thanh | - |
dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Ro, Jai Youl | - |
dc.contributor.author | Kong, Yoon | - |
dc.contributor.author | Lee, Dong-Soon | - |
dc.contributor.author | Lee, Sang-Do | - |
dc.contributor.author | Lee, Yun-Song | - |
dc.contributor.author | Oh, Yeon-Mock | - |
dc.contributor.author | Ahn, Jee-Yin | - |
dc.contributor.author | Bae, Young-An | - |
dc.date.accessioned | 2012-05-23T01:13:07Z | - |
dc.date.available | 2012-05-23T01:13:07Z | - |
dc.date.issued | 2009-04-30 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE; Vol.41 4; 277-287 | ko_KR |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76290 | - |
dc.description.abstract | Matrix metalloproteinase-9 (MMP-9) may play an important role in emphysematous change in chronic obstructive pulmonary disease (COPD), one of the leading causes of mortality and morbidity worldwide. We previously reported that simvastatin, an inhibitor of HMG-CoA reductase, attenuates emphysematous change and MMP-9 induction in the lungs of rats exposed to cigarette smoke. However, it remained uncertain how cigarette smoke induced MMP-9 and how simvastatin inhibited cigarette smoke-induced MMP-9 expression in alveolar macrophages (AMs), a major source of MMP-9 in the lungs of COPD patients. Presently, we examined the related signaling for MMP-9 induction and the inhibitory mechanism of simvastatin on MMP-9 induction in AMs exposed to cigarette smoke extract (CSE). In isolated rat AMs, CSE induced MMP-9 expression and phosphorylation of ERK and Akt. A chemical inhibitor of MEK1/2 or PI3K reduced phosphorylation of ERK or Akt, respectively, and also inhibited CSE-mediated MMP-9 induction. Simvastatin reduced CSE-mediated MMP-9 induction, and simvastatin-mediated inhibition was reversed by farnesyl pyrophosphate (FPP) or geranylgeranyl pyrophosphate (GGPP). Similar to simvastatin, inhibition of FPP transferase or GGPP transferase suppressed CSE-mediated MMP-9 induction. Simvastatin attenuated CSE-mediated activation of RAS and phosphorylation of ERK, Akt, p65, I kappa B, and nuclear AP-1 or NF-kappa B activity. Taken together, these results suggest that simvastatin may inhibit CSE-mediated MMP-9 induction, primarily by blocking prenylation of RAS in the signaling pathways, in which Raf-MEK-ERK, PI3K/Akt, AP-1, and I kappa B-NF-kappa B are involved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | ko_KR |
dc.subject | macrophages, alveolar | ko_KR |
dc.subject | matrix metalloproteinases-9 | ko_KR |
dc.subject | simvastatin | ko_KR |
dc.subject | pulmonary emphysema | ko_KR |
dc.subject | pulmonary disease, chronic obstructive | ko_KR |
dc.subject | smoking | ko_KR |
dc.title | Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김상은 | - |
dc.contributor.AlternativeAuthor | ThuyTran Thi Thanh | - |
dc.contributor.AlternativeAuthor | 이지현 | - |
dc.contributor.AlternativeAuthor | 노재율 | - |
dc.contributor.AlternativeAuthor | 배영안 | - |
dc.contributor.AlternativeAuthor | 공윤 | - |
dc.contributor.AlternativeAuthor | 안지인 | - |
dc.contributor.AlternativeAuthor | 이동순 | - |
dc.contributor.AlternativeAuthor | 오연목 | - |
dc.contributor.AlternativeAuthor | 이상도 | - |
dc.contributor.AlternativeAuthor | 이윤송 | - |
dc.identifier.doi | 10.3858/emm.2009.41.4.031 | - |
dc.citation.journaltitle | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.description.citedreference | Han SW, 2011, J BIOL CHEM, V286, P25416, DOI [10.1074/jbc.M604013200, 10.1074/jbc.M60413200] | - |
dc.description.citedreference | Brass DM, 2008, AM J RESP CELL MOL, V39, P584, DOI 10.1165/rcmb.2007-0448OC | - |
dc.description.citedreference | Yang SR, 2008, AM J RESP CELL MOL, V38, P689, DOI 10.1165/rcmb.2007-0379OC | - |
dc.description.citedreference | Foronjy R, 2008, AM J PHYSIOL-LUNG C, V294, pL1149, DOI 10.1152/ajplung.00481.2007 | - |
dc.description.citedreference | Reynolds PR, 2008, AM J PHYSIOL-LUNG C, V294, pL1094, DOI 10.1152/ajplung.00318.2007 | - |
dc.description.citedreference | Takahashi S, 2008, AM J PHYSIOL-LUNG C, V294, pL882, DOI 10.1152/ajplung.00238.2007 | - |
dc.description.citedreference | Rabe KF, 2007, AM J RESP CRIT CARE, V176, P532, DOI 10.1164/rccm.200703-456SO | - |
dc.description.citedreference | Kim HS, 2007, EXP MOL MED, V39, P106 | - |
dc.description.citedreference | KONSTANTINOPOUL.PA, 2007, NAT REV DRUG DISCOV, V6, P541 | - |
dc.description.citedreference | Cheng JCH, 2006, ONCOGENE, V25, P7009, DOI 10.1038/sj.onc.1209706 | - |
dc.description.citedreference | Lee KW, 2006, INT J CANCER, V119, P1767, DOI 10.1002/ijc.22056 | - |
dc.description.citedreference | Yang SR, 2006, AM J PHYSIOL-LUNG C, V291, pL46, DOI 10.1152/ajplung.00241.2005 | - |
dc.description.citedreference | Jain MK, 2005, NAT REV DRUG DISCOV, V4, P977, DOI 10.1038/nrd1901 | - |
dc.description.citedreference | Lee LH, 2005, AM J RESP CRIT CARE, V172, P987, DOI 10.1164/rccm.200501-041OC | - |
dc.description.citedreference | Lu YB, 2005, J LEUKOCYTE BIOL, V78, P259, DOI 10.1189/jlb.0904498 | - |
dc.description.citedreference | Takada Y, 2005, J BIOL CHEM, V280, P17203, DOI 10.1074/jbc.M500077200 | - |
dc.description.citedreference | Turner NA, 2005, FASEB J, V19, P804, DOI 10.1096/fj.04-2852fje | - |
dc.description.citedreference | Liao JK, 2005, ANNU REV PHARMACOL, V45, P89, DOI 10.1146/annurev.pharmtox.45.120403.095748 | - |
dc.description.citedreference | Moodie FM, 2004, FASEB J, V18, P1897, DOI 10.1096/fj.04-1506fje | - |
dc.description.citedreference | Chung TW, 2004, FASEB J, V18, P1123, DOI 10.1096/fj.03-1429fje | - |
dc.description.citedreference | Mercer BA, 2004, J BIOL CHEM, V279, P17690, DOI 10.1074/jbc.M313842200 | - |
dc.description.citedreference | Moon SK, 2004, J CELL PHYSIOL, V198, P417, DOI 10.1002/jcp.10435 | - |
dc.description.citedreference | BARNES PJ, 2004, J COPD, V1, P59 | - |
dc.description.citedreference | Barnes PJ, 2003, EUR RESPIR J, V22, P672, DOI 10.1183/09031936.03.00040703 | - |
dc.description.citedreference | Lai WC, 2003, J IMMUNOL, V170, P6244 | - |
dc.description.citedreference | Churg A, 2003, AM J RESP CRIT CARE, V167, P1083, DOI 10.1164/rccm.200212-1396OC | - |
dc.description.citedreference | Anderson GP, 2003, TRENDS PHARMACOL SCI, V24, P71, DOI 10.1016/S0165-6147(02)00052-4 | - |
dc.description.citedreference | Culpitt SV, 2003, AM J RESP CRIT CARE, V167, P24, DOI 10.1164/rccm.200204-298OC | - |
dc.description.citedreference | Eberhardt W, 2002, MOL ENDOCRINOL, V16, P1752, DOI 10.1210/me2001-0278 | - |
dc.description.citedreference | Russell REK, 2002, AM J RESP CELL MOL, V26, P602 | - |
dc.description.citedreference | Meshi B, 2002, AM J RESP CELL MOL, V26, P52 | - |
dc.description.citedreference | Denoyelle C, 2001, CARCINOGENESIS, V22, P1139 | - |
dc.description.citedreference | Aikawa M, 2001, CIRCULATION, V103, P276 | - |
dc.description.citedreference | AOSHIBA K, 2001, AM J PHYSIOL-LUNG C, V281, P1392 | - |
dc.description.citedreference | Eberhardt W, 2000, J IMMUNOL, V165, P5788 | - |
dc.description.citedreference | Van den Steen PE, 2000, BLOOD, V96, P2673 | - |
dc.description.citedreference | Lim S, 2000, AM J RESP CRIT CARE, V162, P1355 | - |
dc.description.citedreference | Punturieri A, 2000, J EXP MED, V192, P789 | - |
dc.description.citedreference | Law BK, 2000, J BIOL CHEM, V275, P10796 | - |
dc.description.citedreference | Wang IK, 2000, ONCOLOGY-BASEL, V59, P245 | - |
dc.description.citedreference | Betsuyaku T, 1999, AM J RESP CRIT CARE, V159, P1985 | - |
dc.description.citedreference | GIBBS DF, 1999, AM J RESP CELL MOL B | - |
dc.description.citedreference | Di Stefano A, 1998, AM J RESP CRIT CARE, V158, P1277 | - |
dc.description.citedreference | Ohnishi K, 1998, LAB INVEST, V78, P1077 | - |
dc.description.citedreference | GEARING AJ, 1998, NATURE, V370, P555 | - |
dc.description.citedreference | Whyte DB, 1997, J BIOL CHEM, V272, P14459 | - |
dc.description.citedreference | Gum R, 1997, ONCOGENE, V14, P1481 | - |
dc.description.citedreference | FINKELSTEIN R, 1995, AM J RESP CRIT CARE, V152, P1666 | - |
dc.description.citedreference | KOHL NE, 1993, SCIENCE, V260, P1934 | - |
dc.description.tc | 9 | - |
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