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Patient HSP70-hom TG haplotype is associated with decreased transplant-related mortality and improved survival after sibling HLA-matched hematopoietic stem cell transplantation
DC Field | Value | Language |
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dc.contributor.author | Park, Myoung Hee | - |
dc.contributor.author | Park, Seonyang | - |
dc.contributor.author | Kim, Byoung Kook | - |
dc.contributor.author | Kim, Inho | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Yoon, Sung-Soo | - |
dc.contributor.author | Park, Sung Sup | - |
dc.contributor.author | Rhee, Ji Young | - |
dc.contributor.author | Cho, Hyeon Jin | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.contributor.author | Lee, Jong-Eun | - |
dc.contributor.author | Cho, Eun-Young | - |
dc.contributor.author | Kim, Jin Won | - |
dc.date.accessioned | 2012-05-23T01:17:30Z | - |
dc.date.available | 2012-05-23T01:17:30Z | - |
dc.date.issued | 2010-08 | - |
dc.identifier.citation | CLINICAL TRANSPLANTATION; Vol.24 4; 459-466 | ko_KR |
dc.identifier.issn | 0902-0063 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76293 | - |
dc.description.abstract | Heat shock protein 70-hom (HSP70-hom) plays an important role in protein folding and immune responses. Therefore, HSP70-hom gene polymorphisms may act as important factors in predicting the prognosis of patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). To evaluate the role of HSP70-hom gene polymorphisms in the prognosis of patients receiving sibling human leukocyte antigen (HLA)-matched allogeneic HSCT, the HSP70-hom polymorphisms, T2437C and G2763A, were genotyped in 147 patients receiving sibling HLA-matched allogeneic HSCT. Individual diplotypes were estimated from genotype data of the two HSP70-hom polymorphisms using the expectation maximization algorithm. Patients with the 2763GG or GA genotype showed longer overall survival compared with those with the 2763AA genotype, and patients with a TG haplotype (TG/TA, TG/TG or TG/CG) also showed longer overall survival compared with those with a non-TG haplotype (TA/TA or TA/CG) (both G2763A genotype and diplotype, p < 0.01). Moreover, the 2437TT genotype was found to be protective for treatment-related death compared with the 2437TC genotype, and a TG haplotype was found to be very protective for treatment-related death compared with a non-TG haplotype (T2437C genotype, p = 0.04; and diplotype, p = 0.02). Therefore, our results suggest that HSP70-hom polymorphisms play an important role in the prognosis of patients receiving sibling HLA-matched allogeneic HSCT. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | ko_KR |
dc.subject | haplotype | ko_KR |
dc.subject | polymorphism | ko_KR |
dc.subject | hematopoietic stem cell transplantation | ko_KR |
dc.subject | heat shock protein 70-hom | ko_KR |
dc.title | Patient HSP70-hom TG haplotype is associated with decreased transplant-related mortality and improved survival after sibling HLA-matched hematopoietic stem cell transplantation | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김인호 | - |
dc.contributor.AlternativeAuthor | 김진희 | - |
dc.contributor.AlternativeAuthor | 이지영 | - |
dc.contributor.AlternativeAuthor | 김진원 | - |
dc.contributor.AlternativeAuthor | 조현진 | - |
dc.contributor.AlternativeAuthor | 조은영 | - |
dc.contributor.AlternativeAuthor | 이종은 | - |
dc.contributor.AlternativeAuthor | 홍윤철 | - |
dc.contributor.AlternativeAuthor | 박성섭 | - |
dc.contributor.AlternativeAuthor | 윤성수 | - |
dc.contributor.AlternativeAuthor | 박명희 | - |
dc.contributor.AlternativeAuthor | 박선양 | - |
dc.contributor.AlternativeAuthor | 김병국 | - |
dc.identifier.doi | 10.1111/j.1399-0012.2009.01094.x | - |
dc.citation.journaltitle | CLINICAL TRANSPLANTATION | - |
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dc.description.tc | 0 | - |
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