Browse

Usefulness of routine lumbar puncture in non-HIV patients with latent syphilis of unknown duration

Cited 5 time in Web of Science Cited 10 time in Scopus
Authors
Choe, Pyoeng Gyun; Song, Jin Su; Jeon, Jae Hyun; Song, Kyoung-Ho; Park, Wan Beom; Park, Sang Won; Oh, Myoung-Don; Kim, Hong Bin; Kim, Nam Joong; Park, Kyoung Un
Issue Date
2010-05
Publisher
B M J PUBLISHING GROUP
Citation
SEXUALLY TRANSMITTED INFECTIONS; Vol.86 1; 39-40
Abstract
Objectives To evaluate the usefulness of routine lumbar puncture in non-HIV patients with untreated latent syphilis. Methods We conducted a prospective study in Seoul National University Bundang Hospital from May 2003 to December 2005. Participants in routine health check-ups of the healthcare system were screened for serological evidence of syphilis by the Treponema pallidum particle agglutination (TPPA) test. Lumbar puncture was performed, with consent, on untreated latent syphilitic patients. Neurosyphilis was defined as positivity for cerebrospinal fluid Venereal Disease Research Laboratory (CSF VDRL) or pleocytosis with positivity for CSF TPPA or elevation of CSF protein with IgG index exceeding 0.85. Results Of 21 507 participants, 282 (1.4%) had serological evidence of syphilis. 117 (41%) of these had a history of syphilis treatment and 2 were seropositive for HIV. Among the 163 non-HIV patients with untreated latent syphilis, 70 (43%) underwent lumbar puncture. All the patients had VDRL titres less than 1:16. Abnormal neurological signs or symptoms were present in eight (11%) patients. CSF abnormalities were seen in 57 (81%), but no patient (0%, 95% CI 0 to 6.2) was diagnosed with neurosyphilis. Conclusions The estimated prevalence of neurosyphilis among non-HIV patients with untreated latent syphilis and serum VDRL < 1:16, was below 6.2%.
ISSN
1368-4973
Language
English
URI
http://hdl.handle.net/10371/76302
DOI
https://doi.org/10.1136/sti.2009.037267
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse