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Cost-effectiveness analysis of adjuvant therapy for node positive breast cancer in Korea: docetaxel, doxorubicin and cyclophosphamide (TAC) versus fluorouracil, doxorubicin and cyclophosphamide (FAC)

Cited 30 time in Web of Science Cited 19 time in Scopus
Authors
Lee, Sang Gyu; Jee, Young Geon; Chung, Hyun Chul; Kim, Sung-Bae; Im, Young-Hyuck; Seo, Jae Hong; Im, Seock-Ah; Ro, Jungsil
Issue Date
2009-04
Publisher
SPRINGER
Citation
BREAST CANCER RESEARCH AND TREATMENT; Vol.114 3; 589-595
Keywords
Adjuvant therapyBreast cancerCost-effectivenessKoreanTaxanes
Abstract
Background This study evaluated the incremental cost-effectiveness (ICER) and cost-utility ratios (ICUR) of TAC compared with FAC following primary surgery for node positive breast cancer patients in Korea. Materials and methods A cost-effectiveness analysis was performed using the Markov model from the combined view of Korean National Health Insurance and patients. The model allowed assessment from the beginning of the first cycle of adjuvant chemotherapy following primary surgery until death. Relevant clinical data were obtained from the clinical trial BCIRG 001 and data for local treatment patterns and direct medical costs were obtained from three Korean hospitals. Results Over a life time horizon, the life expectancy of TAC was 0.9 years longer than that of FAC. The ICER was 8,025,879 Korean won (KW, a,not sign6,573) per life year gained and the ICUR was 8,885,794 KW (a,not sign7,277) per QALY gained when the cost and effectiveness were discounted at 5%. The model was most sensitive to the percent patient receiving prophylactic granulocyte colony stimulating factor (G-CSF) in TAC arm and the ICUR was 12,119,561 KW (a,not sign9,926) when assuming 100%. Conclusions TAC appears to be cost-effective in the management of early breast cancer in Korea.
ISSN
0167-6806
Language
English
URI
http://hdl.handle.net/10371/76341
DOI
https://doi.org/10.1007/s10549-008-0035-0
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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