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Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma
DC Field | Value | Language |
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dc.contributor.author | Kim, Sang-Heon | - |
dc.contributor.author | Kim, Yoon-Keun | - |
dc.contributor.author | Park, Heung-Woo | - |
dc.contributor.author | Kim, Sang-Hoon | - |
dc.contributor.author | Ye, Young-Min | - |
dc.contributor.author | Park, Hae-Sim | - |
dc.contributor.author | Min, Kyung-Up | - |
dc.contributor.author | Kim, Seung-Hyun | - |
dc.date.accessioned | 2012-05-24T00:28:08Z | - |
dc.date.available | 2012-05-24T00:28:08Z | - |
dc.date.issued | 2009-03 | - |
dc.identifier.citation | RESPIRATORY MEDICINE; Vol.103 3; 356-363 | ko_KR |
dc.identifier.issn | 0954-6111 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76362 | - |
dc.description.abstract | In asthmatic airways, adenosine is a potent bronchoconstrictor with either pro- or anti-inflammatory effects depending on receptor interactions. While aspirin has been suggested to mediate adenosine action, the roles of adenosine and its receptors in aspirin-intolerant asthma (AIA) are not well-defined. Therefore, we evaluated associations between genetic polymorphisms of adenosine deaminase and the four adenosine receptors (A(1), A(2A), A(2B), and A(3)) with the AIA phenotype. The genes for adenosine deaminase (ADA) and the four adenosine receptors (ADORA1, ADORA2A, ADORA2B, and ADORA3) were screened by direct sequencing, and 13 single nucleotide polymorphisms (SNPs) were selected among 23 polymorphisms. Using multivariate logistic regression analysis, we compared the frequencies of SNP genotypes and haplotypes among 136 patients with AIA, 181 patients with aspirin-tolerant asthma (ATA), and 183 normal individuals. We found significant differences between normal and patients with AIA in the ADORA1 SNP genotype frequencies for 1405C > T (P = 0.001) and A102A (P = 0.013). No other significant associations were detected for the other SNPs. In the haplotype analysis, ht[C-T-G] (P = 0.003) and ht[A-C-G] (P = 0.032) in ADORA1 and ht[A-T] in ADORA2 (P = 0.013) were significantly associated with AIA. Genetic polymorphisms of adenosine receptors A(1) and A(2A) were associated with AIA, suggesting that adenosine might play a crucial role in the development of AIA through interactions with the A(1) and A(2A) receptors. (C) 2008 Elsevier Ltd. All rights reserved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | W B SAUNDERS CO LTD | ko_KR |
dc.subject | Aspirin-intolerant asthma | ko_KR |
dc.subject | Adenosine receptors | ko_KR |
dc.subject | Adenosine deaminase | ko_KR |
dc.subject | Polymorphism | ko_KR |
dc.title | Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김상헌 | - |
dc.contributor.AlternativeAuthor | 김윤근 | - |
dc.contributor.AlternativeAuthor | 박흥우 | - |
dc.contributor.AlternativeAuthor | 김상훈 | - |
dc.contributor.AlternativeAuthor | 김승현 | - |
dc.contributor.AlternativeAuthor | 예영민 | - |
dc.contributor.AlternativeAuthor | 민경업 | - |
dc.contributor.AlternativeAuthor | 박해심 | - |
dc.identifier.doi | 10.1016/j.rmed.2008.10.008 | - |
dc.citation.journaltitle | RESPIRATORY MEDICINE | - |
dc.description.citedreference | Brown RA, 2008, EUR RESPIR J, V31, P311, DOI 10.1183/09031936.00003707 | - |
dc.description.citedreference | Kim SH, 2008, PHARMACOGENOMICS, V9, P85, DOI 10.2217/14622416.9.1.85 | - |
dc.description.citedreference | Tang Z, 2007, CLIN PHARMACOL THER, V82, P435, DOI 10.1038/sj.clpt.6100331 | - |
dc.description.citedreference | Nadeem A, 2007, AM J PHYSIOL-LUNG C, V292, pL1335, DOI 10.1152/ajplung.00416.2006 | - |
dc.description.citedreference | Kim SH, 2007, PHARMACOGENET GENOM, V17, P295, DOI 10.1097/01.fpc.0000239977.61841.fe | - |
dc.description.citedreference | Mustafa SJ, 2007, J PHARMACOL EXP THER, V320, P1246, DOI 10.1124/jpet.106.112250 | - |
dc.description.citedreference | Chen JM, 2006, HUM GENET, V120, P301, DOI 10.1007/s00439-006-0218-x | - |
dc.description.citedreference | Gloria-Bottini F, 2006, ALLERGY ASTHMA PROC, V27, P115 | - |
dc.description.citedreference | Kim SH, 2006, CURR OPIN ALLERGY CL, V6, P17 | - |
dc.description.citedreference | Odashima M, 2006, WORLD J GASTROENTERO, V12, P568 | - |
dc.description.citedreference | Liu Y, 2006, J ASTHMA, V43, P203, DOI 10.1080/02770900600566827 | - |
dc.description.citedreference | Obiefuna PCM, 2005, J PHARMACOL EXP THER, V315, P329, DOI 10.1124/jpet.105.088179 | - |
dc.description.citedreference | Park JS, 2005, PHARMACOGENET GENOM, V15, P483 | - |
dc.description.citedreference | Kim SH, 2005, CLIN EXP ALLERGY, V35, P585, DOI 10.1111/j.1365-2222.2005.02220.x | - |
dc.description.citedreference | Csoma Z, 2005, EUR RESPIR J, V25, P873, DOI 10.1183/09031936.05.00110204 | - |
dc.description.citedreference | Tang CM, 2005, PHARMACOGENET GENOM, V15, P321 | - |
dc.description.citedreference | Sun CX, 2005, J CLIN INVEST, V115, P35, DOI 10.1172/JCI200522656 | - |
dc.description.citedreference | Young HWJ, 2004, J IMMUNOL, V173, P1380 | - |
dc.description.citedreference | Choi JH, 2004, HUM GENET, V114, P337, DOI 10.1007/s00439-004-1082-1 | - |
dc.description.citedreference | Sitkovsky MV, 2004, ANNU REV IMMUNOL, V22, P657, DOI 10.1146/annurev.immunol.22.012703.104731 | - |
dc.description.citedreference | Han W, 2004, CLIN CANCER RES, V10, P124 | - |
dc.description.citedreference | Fozard JR, 2002, EUR J PHARMACOL, V438, P183 | - |
dc.description.citedreference | RORKE S, 2002, AM J RESP MED, V1, P99 | - |
dc.description.citedreference | Fredholm BB, 2001, PHARMACOL REV, V53, P527 | - |
dc.description.citedreference | Popa V, 2001, AM J RESP CRIT CARE, V163, P292 | - |
dc.description.citedreference | Szczeklik A, 2000, EUR RESPIR J, V16, P432 | - |
dc.description.citedreference | Blackburn MR, 2000, J EXP MED, V192, P159 | - |
dc.description.citedreference | Cronstein BN, 1999, OSTEOARTHR CARTILAGE, V7, P361 | - |
dc.description.citedreference | Cronstein BN, 1999, P NATL ACAD SCI USA, V96, P6377 | - |
dc.description.citedreference | Ezeamuzie CI, 1999, BRIT J PHARMACOL, V127, P188 | - |
dc.description.citedreference | Sanak M, 1997, LANCET, V350, P1599 | - |
dc.description.citedreference | Walker BAM, 1997, AM J RESP CELL MOL, V16, P531 | - |
dc.description.citedreference | Nyce JW, 1997, NATURE, V385, P721 | - |
dc.description.citedreference | CRIMI N, 1995, EUR RESPIR J, V8, P905 | - |
dc.description.citedreference | PARK HS, 1995, CLIN EXP ALLERGY, V25, P38 | - |
dc.description.citedreference | CRONSTEIN BN, 1994, INFLAMMATION, V18, P323 | - |
dc.description.citedreference | DRIVER AG, 1993, AM REV RESPIR DIS, V148, P91 | - |
dc.description.citedreference | BJORCK T, 1992, AM REV RESPIR DIS, V145, P1087 | - |
dc.description.citedreference | CRONSTEIN BN, 1992, J IMMUNOL, V148, P2201 | - |
dc.description.citedreference | MANN JS, 1986, J APPL PHYSIOL, V61, P1667 | - |
dc.description.citedreference | CRONSTEIN BN, 1985, J IMMUNOL, V135, P1366 | - |
dc.description.citedreference | HUGHES PJ, 1984, BIOCHEM PHARMACOL, V33, P3847 | - |
dc.description.citedreference | RONCHETTI R, 1984, J ALLERGY CLIN IMMUN, V74, P81 | - |
dc.description.citedreference | CUSHLEY MJ, 1983, BRIT J CLIN PHARMACO, V15, P161 | - |
dc.description.tc | 12 | - |
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