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Long-Term Exercise Training Attenuates Age-Related Diastolic Dysfunction: Association of Myocardial Collagen Cross-Linking

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dc.contributor.authorChoi, Su-Yeon-
dc.contributor.authorChang, Hyuk-Jae-
dc.contributor.authorChoi, Sang-Il-
dc.contributor.authorKim, Kwang-Il-
dc.contributor.authorYoun, Tae-Jin-
dc.contributor.authorChae, In-Ho-
dc.contributor.authorKim, Hyo-Soo-
dc.contributor.authorOh, Byung-Hee-
dc.contributor.authorKim, Mi-Hyang-
dc.contributor.authorKim, Cheol-Ho-
dc.contributor.authorChoi, Dong-Ju-
dc.contributor.authorChung, Woo-Young-
dc.contributor.authorCho, Yong-Seok-
dc.date.accessioned2012-05-24T01:25:16Z-
dc.date.available2012-05-24T01:25:16Z-
dc.date.issued2009-02-
dc.identifier.citationJOURNAL OF KOREAN MEDICAL SCIENCE; Vol.24 1; 32-39ko_KR
dc.identifier.issn1011-8934-
dc.identifier.urihttp://hdl.handle.net/10371/76376-
dc.description.abstractThe incidence of diastolic heart failure increases dramatically with age. We investigated the impact of long-term exercise training on age-related diastolic dysfunction. Old (25-month-old) male Fischer 344 rats were studied after 12 weeks of treadmill exercise training or sedentary cage life (N=7, in each group). We determined cardiac performance using a pressure-volume conductance catheter and magnetic resonance imaging. Collagen volume fraction (CVF) and myocardial collagen solubility by pepsin as an index of advanced glycation end products (AGEs) crosslinked collagen were measured. The maximal slope of systolic pressure increment (+dP/dt) and the slope of end-systolic pressure-volume relation were higher, and end diastolic volume (EDV), Delta EDV (the percentage of the EDV increment-to-baseline EDV) and the slope of end-diastolic pressure-volume relation were lower in training group. The maximal slope of diastolic pressure decrement (-dP/dt) and time constant of LV pressure decay (tau) had no difference. AGEs cross-linked collagen, not CVF was reduced by exercise training. Long-term exercise training appears to attenuate age-related deterioration in cardiac systolic function and myocardial stiffness and could be reduce in pathologic AGEs cross-linked collagen in myocardium.ko_KR
dc.description.sponsorshipThis work was supported by Seoul National University
Research fund 800-20050034 and the Korean Society
of Circulation Research fund 06-05-050, Seoul, Korea.
ko_KR
dc.language.isoenko_KR
dc.publisherKOREAN ACAD MEDICAL SCIENCESko_KR
dc.subjectAgingko_KR
dc.subjectExerciseko_KR
dc.subjectGlycosylation End Productsko_KR
dc.subjectAdvancedko_KR
dc.subjectDiastoleko_KR
dc.titleLong-Term Exercise Training Attenuates Age-Related Diastolic Dysfunction: Association of Myocardial Collagen Cross-Linkingko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor최수연-
dc.contributor.AlternativeAuthor장혁재-
dc.contributor.AlternativeAuthor최상일-
dc.contributor.AlternativeAuthor김광일-
dc.contributor.AlternativeAuthor조용석-
dc.contributor.AlternativeAuthor연태진-
dc.contributor.AlternativeAuthor정우영-
dc.contributor.AlternativeAuthor채인호-
dc.contributor.AlternativeAuthor최동주-
dc.contributor.AlternativeAuthor김효수-
dc.contributor.AlternativeAuthor김철호-
dc.contributor.AlternativeAuthor오병희-
dc.contributor.AlternativeAuthor김미향-
dc.identifier.doi10.3346/jkms.2009.24.1.32-
dc.citation.journaltitleJOURNAL OF KOREAN MEDICAL SCIENCE-
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