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Impact of Toxocariasis in Patients with Unexplained Patchy Pulmonary Infiltrate in Korea

Cited 19 time in Web of Science Cited 23 time in Scopus
Authors
Yoon, Young-Soon; Lee, Chang-Hoon; Kang, Young-Ae; Kwon, Sung-Youn; Lee, Jae-Ho; Lee, Choon-Taek; Yoon, Ho Il
Issue Date
2009-02
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.24 1; 40-45
Keywords
ToxocariasisEosinophiliaPulmonary InfiltrateRaw Cow Liver
Abstract
Toxocariasis is one of the causes of pulmonary eosinophilic infiltrate that is increasing in Korea. This study was designed to identify the prevalence of toxocara seropositivity in patients with unexplained pulmonary patchy infiltrate and to evaluate associated factors. We evaluated 102 patients with unexplained pulmonary patchy infiltrate on chest computed tomography (CT) scan. As a control set, 116 subjects with normal chest CT were also evaluated. History of allergic disease, drug use, parasitic disease and raw cow liver intake were taken. Blood eosinophil count and total IgE level were measured. Specific serum IgG antibody to Toxocara canis larval antigen and specific IgG antibodies to 4 other parasites were measured by enzyme-linked immunosorbent assay (ELISA). In the infiltrate group, 66.7% subjects were toxocara seropositive whereas 22.4% of the control group were seropositive (p<0.001). In the infiltrate group, patients with a history of eating raw cow liver (odds ratio [OR], 7.8) and patients with eosinophilia (OR, 5.2) had a higher incidence of toxocara seropositivity. Thirty-five percent of toxocara seropositive patients with infiltrate exhibited migrating infiltrate and 48% had decreased infiltrate on the follow-up CT. We recommend that toxocara ELISA should be performed in patients with unexplained pulmonary patchy infiltrate, and that the eating of raw cow liver should be actively discouraged.
ISSN
1011-8934
Language
English
URI
http://hdl.handle.net/10371/76377
DOI
https://doi.org/10.3346/jkms.2009.24.1.40
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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