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DOES ADJUVANT RADIOTHERAPY SUPPRESS LIVER REGENERATION AFTER PARTIAL HEPATECTOMY?

Cited 3 time in Web of Science Cited 4 time in Scopus
Authors
Choi, Jin-Hwa; Kim, Kyubo; Chie, Eui Kyu; Jang, Jin-Young; Oh, Do-Youn; Kim, Tae-You; Ha, Sung W.; Bang, Yung-Jue; Im, Seock-Ah; Kim, Sun Whe
Issue Date
2009-05-01
Publisher
ELSEVIER SCIENCE INC
Citation
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS; Vol.74 1; 67-72
Keywords
Liver regenerationBiliary tract cancerRadiotherapyAdjuvant therapy
Abstract
Purpose: To analyze the influence of the adjuvant radiotherapy (RT) on the liver regeneration and liver function after partial hepatectomy (PH). Methods and Materials: Thirty-four patients who underwent PH for biliary tract cancer between October 2003 and July 2005 were reviewed. Hemihepatectomy was performed in 14 patients and less extensive surgery in 20. Of the patients, 19 patients had no adjuvant therapy (non-RT group) and 15 underwent adjuvant RT by a three-dimensional conformal technique (RT group). Radiation dose range was 40 to 50 Gy (median, 40 Gy). Liver volume on computed tomography and the results of liver function tests at 1, 4, 12, 24, and 52 weeks after PH were compared between the RT and non-RT groups. Results: The preoperative characteristics were identical for both groups. During the interval between Weeks 4 and 12 when adjuvant RT was delivered in the RT group, the increase in liver volume was significantly smaller in the RT group than non-RT group (22.9 +/- 38.3cm(3) and 81.5 +/- 75.6cm(3), respectively,p = 0.007). However, the final liver volume measured at 1 year after PH did not differ between the two groups (p = 0.878). Liver function tests were comparable for both groups. The resection extent and original liver volume was independent factors for final liver volume measured at 1 year after PH. Conclusions: In this study, adjuvant RT delayed the liver regeneration process after PH, but the volume difference between the two study groups became nonsignificant after I year. Adjuvant RT had no additional adverse effect on liver function after PH. (C) 2009 Elsevier Inc.
ISSN
0360-3016
Language
English
URI
http://hdl.handle.net/10371/76430
DOI
https://doi.org/10.1016/j.ijrobp.2008.06.1941
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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