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Cathepsin B is a target of Hedgehog signaling in pancreatic cancer

Cited 19 time in Web of Science Cited 22 time in Scopus
Authors
Hwang, Jin-Hyeok; Lee, Sang Hyub; Lee, Kwang Hyuck; Lee, Keung Youp; Ryu, Ji Kon; Kim, Yong-Tae; Yoon, Yong Bum; Kim, Haeryoung
Issue Date
2009-01-18
Publisher
ELSEVIER IRELAND LTD
Citation
CANCER LETTERS; Vol.273 2; 266-272
Keywords
Pancreatic cancerHedgehog geneCathepsin BInvasion
Abstract
This study investigated the influence of cathepsin B (CATB), a downstream target of Hedgehog (Hh) signaling, in pancreatic cancer. Cyclopamine (Hh signal inhibitor) suppressed expression of Shh, as well as Hh-induced transcription factor Gli1, and induced apoptosis in Shh-positive pancreatic cancer cell line (PANC-1). Microarray analysis revealed CATB as a gene downregulated by Hh. Cyclopamine reduced CATB protein and mRNA levels. Cyclopamine or CATB inhibitor reduced PANC-1 cell invasiveness (P < 0.05). CATB expression in human pancreatic cancer tissues tended to correlate with Shh expression (P = 0.053). Conclusively, Hh targets CATB and Hh signaling through CATB might influence pancreatic cancer cell invasiveness. (C) 2008 Published by Elsevier Ireland Ltd.
ISSN
0304-3835
Language
English
URI
http://hdl.handle.net/10371/76453
DOI
https://doi.org/10.1016/j.canlet.2008.08.028
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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