서울대학교 중앙도서관
S-Space 소개
My S-Space
로그인이 필요합니다.
Login

S-Space

Publications

Detailed Information

Cathepsin B is a target of Hedgehog signaling in pancreatic cancer

DC Field Value Language
dc.contributor.authorHwang, Jin-Hyeok-
dc.contributor.authorLee, Sang Hyub-
dc.contributor.authorLee, Kwang Hyuck-
dc.contributor.authorLee, Keung Youp-
dc.contributor.authorRyu, Ji Kon-
dc.contributor.authorKim, Yong-Tae-
dc.contributor.authorYoon, Yong Bum-
dc.contributor.authorKim, Haeryoung-
dc.date.accessioned2012-05-25T02:21:40Z-
dc.date.available2012-05-25T02:21:40Z-
dc.date.issued2009-01-18-
dc.identifier.citationCANCER LETTERS; Vol.273 2; 266-272ko_KR
dc.identifier.issn0304-3835-
dc.identifier.urihttps://hdl.handle.net/10371/76453-
dc.description.abstractThis study investigated the influence of cathepsin B (CATB), a downstream target of Hedgehog (Hh) signaling, in pancreatic cancer. Cyclopamine (Hh signal inhibitor) suppressed expression of Shh, as well as Hh-induced transcription factor Gli1, and induced apoptosis in Shh-positive pancreatic cancer cell line (PANC-1). Microarray analysis revealed CATB as a gene downregulated by Hh. Cyclopamine reduced CATB protein and mRNA levels. Cyclopamine or CATB inhibitor reduced PANC-1 cell invasiveness (P < 0.05). CATB expression in human pancreatic cancer tissues tended to correlate with Shh expression (P = 0.053). Conclusively, Hh targets CATB and Hh signaling through CATB might influence pancreatic cancer cell invasiveness. (C) 2008 Published by Elsevier Ireland Ltd.ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER IRELAND LTDko_KR
dc.subjectPancreatic cancerko_KR
dc.subjectHedgehog geneko_KR
dc.subjectCathepsin Bko_KR
dc.subjectInvasionko_KR
dc.titleCathepsin B is a target of Hedgehog signaling in pancreatic cancerko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor황진혁-
dc.contributor.AlternativeAuthor이상협-
dc.contributor.AlternativeAuthor이광혁-
dc.contributor.AlternativeAuthor이긍엽-
dc.contributor.AlternativeAuthor김혜령-
dc.contributor.AlternativeAuthor류지곤-
dc.contributor.AlternativeAuthor윤용범-
dc.contributor.AlternativeAuthor김용태-
dc.identifier.doi10.1016/j.canlet.2008.08.028-
dc.citation.journaltitleCANCER LETTERS-
dc.description.citedreferenceCzyzewska J, 2008, FOLIA HISTOCHEM CYTO, V46, P57, DOI 10.2478/v10042-008-0007-6-
dc.description.citedreferenceHu WG, 2007, ACTA PHARMACOL SIN, V28, P1224, DOI 10.1111/j.1745-7254.2007.00620.x-
dc.description.citedreferenceEbert MPA, 2005, PROTEOMICS, V5, P1693, DOI 10.1002/pmic.200401030-
dc.description.citedreferenceNiedergethmann M, 2004, PANCREAS, V29, P204-
dc.description.citedreferenceBerman DM, 2003, NATURE, V425, P846, DOI 10.1038/nature01972-
dc.description.citedreferenceThayer SP, 2003, NATURE, V425, P851, DOI 10.1038/nature02009-
dc.description.citedreferenceLee HS, 2003, J PATHOL, V200, P39, DOI 10.1002/path.1288-
dc.description.citedreferenceYang SH, 2003, INT J ONCOL, V22, P741-
dc.description.citedreferenceWatkins DN, 2003, NATURE, V422, P313, DOI 10.1038/nature01493-
dc.description.citedreferenceBervar A, 2003, BIOL CHEM, V384, P447-
dc.description.citedreferenceHebrok M, 2003, MECH DEVELOP, V120, P45-
dc.description.citedreferenceTZANAKAKIS GN, 2003, INT J GASTROINT CANC, V34, P27-
dc.description.citedreferenceMullor JL, 2002, TRENDS CELL BIOL, V12, P562-
dc.description.citedreferenceIngham PW, 2001, GENE DEV, V15, P3059-
dc.description.citedreferenceSzpaderska AM, 2001, CANCER RES, V61, P3493-
dc.description.citedreferenceBale AE, 2001, HUM MOL GENET, V10, P757-
dc.description.citedreferenceFrohlich E, 2001, CANCER, V91, P972-
dc.description.citedreferenceWechsler-Reya R, 2001, ANNU REV NEUROSCI, V24, P385-
dc.description.citedreferenceHerszenyi L, 2000, CLIN CHIM ACTA, V291, P171-
dc.description.citedreferenceFujise N, 2000, LUNG CANCER-J IASLC, V27, P19-
dc.description.citedreferenceWerle B, 1999, BRIT J CANCER, V81, P510-
dc.description.citedreferenceStrojnik T, 1999, CLIN CANCER RES, V5, P559-
dc.description.citedreferenceELLENRIEDER V, 1999, ANN ONCOL S4, V10-
dc.description.citedreferenceLiu Y, 1998, CHINESE MED J-PEKING, V111, P784-
dc.description.citedreferenceHebrok M, 1998, GENE DEV, V12, P1705-
dc.description.citedreferenceNakae T, 1998, TUMOR BIOL, V19, P118-
dc.description.citedreferenceKos J, 1997, CLIN CANCER RES, V3, P1815-
dc.description.citedreferenceChiang C, 1996, NATURE, V383, P407-
dc.description.citedreferenceThomssen C, 1995, CLIN CANCER RES, V1, P741-
dc.description.citedreferenceSINHA AA, 1995, ANAT REC, V241, P353-
dc.description.citedreferenceREMPEL SA, 1994, CANCER RES, V54, P6027-
dc.description.citedreferenceCASTIGLIONI T, 1994, HUM PATHOL, V25, P857-
dc.description.citedreferenceDUFFY MJ, 1992, CLIN EXP METASTAS, V10, P145-
dc.description.citedreferenceSHUJA S, 1991, INT J CANCER, V49, P341-
dc.description.citedreferencePOLGAR L, 1990, BIOL CHEM H-S, V371, P327-
dc.description.citedreferenceWATANABE M, 1989, BIOCHEM MED METAB B, V42, P21-
dc.description.citedreferenceCHUNG SM, 1989, GASTROENTEROL JPN, V24, P699-
dc.description.citedreferenceNUSSLEINVOLHARD C, 1980, NATURE, V287, P795-
dc.description.citedreferencePOOLE AR, 1978, NATURE, V273, P545-
dc.description.tc6-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Altmetrics

Item View & Download Count

Show Simple Item Record
Find it @ SNU

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share

qrcode
SNS Share