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Computed Tomography Features of Extensively Drug-Resistant Pulmonary Tuberculosis in Non-HIV-Infected Patients

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dc.contributor.authorLee, Eun Sun-
dc.contributor.authorPark, Chang Min-
dc.contributor.authorGoo, Jin Mo-
dc.contributor.authorYim, Jae-Joon-
dc.contributor.authorLee, Hyun Ju-
dc.contributor.authorIm, Jung-Gi-
dc.contributor.authorLee, In Sun-
dc.contributor.authorKim, Hye-Ryoun-
dc.date.accessioned2012-05-25T07:45:10Z-
dc.date.available2012-05-25T07:45:10Z-
dc.date.issued2010-07-
dc.identifier.citationJOURNAL OF COMPUTER ASSISTED TOMOGRAPHY; Vol.34 4; 559-563ko_KR
dc.identifier.issn0363-8715-
dc.identifier.urihttp://hdl.handle.net/10371/76488-
dc.description.abstractObjective: To describe the computed tomography (CT) findings of pulmonary extensively drug-resistant tuberculosis (XDR-TB) in non-HIV-infected patients and to compare them with those of non-XDR multidrug-resistant tuberculosis (MDR-TB). Methods: Retrospective review of microbiological results and drug-susceptibility tests of 260 non-HIV-infected patients who had been diagnosed with pulmonary MDR-TB from 1994 to 2005 revealed that 47 patients had XDR-TB, whereas the other 213 patients had non-XDR MDR-TB. Twenty of the 47 XDR-TB patients and 85 of the 213 non-XDR MDR-TB patients with available CT examinations were included in this study. Two radiologists reviewed the CT studies in consensus for the presence and extent of micronodules, tree-in-bud appearance, lobular consolidation (<2 cm), consolidation, cavity, bronchiectasis, emphysema, pleural effusion, lymphadenopathy, bronchopleural fistula, and empyema. We then compared the CT features of XDR-TB with those of non-XDR MDR-TB. Results: Micronodules and tree-in-bud appearance were the most frequent CT abnormalities and were seen in all XDR-TB patients (100%). Consolidations, cavities, bronchiectasis, and lobular consolidations were found in 85%, 85%, 80%, and 70% of XDR-TB patients, respectively. The extents of micronodules, tree-in-bud appearance, lobular consolidation, consolidation, cavity, bronchiectasis, and emphysema were 3.60, 3.55, 1.35, 1.85, 1.65, 1.45, and 0.25 lobes, respectively. Compared with non-XDR MDR-TB, XDR-TB showed a significantly larger extent of tree-in-bud appearance and consolidation (P < 0.05). With respect to other CT features, there were no significant differences between XDR-TB and non-XDR MDR-TB. Conclusion: Computed tomography findings of pulmonary XDR-TB are similar to those of non-XDR MDR-TB; however, XDR-TB tends to have more extensive consolidation and tree-in-bud appearance.ko_KR
dc.description.sponsorshipThis study was supported by the research fund of the Radiological Research
Foundation of Korea (2008-01).
ko_KR
dc.language.isoenko_KR
dc.publisherLIPPINCOTT WILLIAMS & WILKINSko_KR
dc.subjectlungko_KR
dc.subjecttuberculosisko_KR
dc.subjectmultidrug-resistantko_KR
dc.subjectcomputed tomographyko_KR
dc.subjectextensively drug-resistant tuberculosisko_KR
dc.titleComputed Tomography Features of Extensively Drug-Resistant Pulmonary Tuberculosis in Non-HIV-Infected Patientsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이은선-
dc.contributor.AlternativeAuthor박창민-
dc.contributor.AlternativeAuthor구진모-
dc.contributor.AlternativeAuthor임재준-
dc.contributor.AlternativeAuthor김혜련-
dc.contributor.AlternativeAuthor이현주-
dc.contributor.AlternativeAuthor이인선-
dc.contributor.AlternativeAuthor임정기-
dc.identifier.doi10.1097/RCT.0b013e3181d472bc-
dc.citation.journaltitleJOURNAL OF COMPUTER ASSISTED TOMOGRAPHY-
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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