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High Serum Bilirubin Is Associated with the Reduced Risk of Diabetes Mellitus and Diabetic Nephropathy

Cited 63 time in Web of Science Cited 63 time in Scopus
Authors
Han, Seung Seok; Na, Ki Young; Chae, Dong-Wan; Kim, Yon Su; Chin, Ho Jun; Kim, Suhnggwon
Issue Date
2010-06
Publisher
TOHOKU UNIV MEDICAL PRESS
Citation
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE; Vol.221 2; 133-140
Keywords
bilirubinmetabolic syndromediabetic nephropathychronic kidney diseasediabetes mellitus
Abstract
Several studies have suggested a potential effect of serum bilirubin as an antioxidant and cytoprotectant factor. For the results presented here, we evaluated the correlation between serum bilirubin and diabetes mellitus (DM) or chronic kidney disease originated from DM (DMCKD) in a Korean population. We used a cross-sectional, population-based design to examine 93,909 subjects (aged 18-96 years, 53.0% male). The trend of P values in the odds ratios for being DM and DMCKD was calculated using patients separated into five groups based on individual serum bilirubin concentrations. The prevalence of DM and DMCKD was 6.7% and 0.8%, respectively. Higher serum bilirubin levels were significantly associated with decreased prevalence of DM in both men (P trend < 0.001) and women (P trend = 0.014). The risk of DMCKD also decreased as bilirubin levels increased in women (P trend = 0.011), but not in men (P trend = 0.467). Serum bilirubin level was inversely related to insulin resistance using the homeostasis model assessment (HOMA-IR), serum insulin, and C-reactive protein (CRP) levels in multiple linear regression analyses. The regression coefficients (B) of log-HOMA-IR, log-insulin, and log-CRP were as follows: -0.09, -0.13, and -0.60 in men; -0.07, -0.09, and -0.50 in women, respectively. All the regressions were statistically significant (P < 0.001). These results indicate that serum bilirubin might have some protective function against DM and DMCKD, although the association between high serum bilirubin and decreased prevalence of DMCKD is observed only in women.
ISSN
0040-8727
Language
English
URI
http://hdl.handle.net/10371/76527
DOI
https://doi.org/10.1620/tjem.221.133
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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