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Outcome of Renal Allograft in Patients With Henoch-Schonlein Nephritis: Single-Center Experience and Systematic Review

Cited 15 time in Web of Science Cited 18 time in Scopus
Authors
Han, Seung Seok; Sun, Hui-Kyoung; Lee, Jung Pyo; Ha, Jong Won; Kim, Yon Su; Kim, Sang Joon
Issue Date
2010-03-27
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
TRANSPLANTATION; Vol.89 6; 721-726
Keywords
DonorRecurrenceHenoch-Schonlein purpuraHenoch-Schonlein nephritis
Abstract
Background. Henoch-Schonlein nephritis (HSN) is a rare condition resulting in end-stage renal disease. Therefore, graft outcomes and recurrence rates after transplantation are not well studied. Also, the effect of donor type on graft outcome has not been evaluated thoroughly. Methods. The graft outcome and recurrence rate in 20 kidney recipients with HSN were compared with age-, sex-, and donor source-matched controls (control A, primary immunoglobulin A nephropathy; control B, other causes; 40 recipients per group). To assess the effect of donor type, we pooled our data with two previous cohort studies where donor type had been described in detail. Results. Overall graft survival rates were 87.7% at 10 years. The overall recurrence rate of HSN was 15.4% over 10 years. Graft survival and recurrence rates in the HSN group were similar to those of control A and control B. The pooled data showed a 29.4% incidence rate for recurrent HSN. Living related donor transplantation showed a trend of higher recurrence compared with recipients with nonrelated grafts, although it was marginally significant (P = 0.059). However, the graft survival rate in related-donor recipients was not inferior to that in the unrelated-donor recipients. Conclusions. Long-term graft survival and recurrence rates in kidney recipients with HSN were comparable to those of recipients with primary immunoglobulin A nephropathy. The type of donor did not significantly affect long-term graft survival.
ISSN
0041-1337
Language
English
URI
http://hdl.handle.net/10371/76530
DOI
https://doi.org/10.1097/TP.0b013e3181c9cc4a
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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