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Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and N-monomethylphytosphingosine, in human leukemia cell line HL60
DC Field | Value | Language |
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dc.contributor.author | Park, Sook Ryun | - |
dc.contributor.author | Cho, Hyo Jin | - |
dc.contributor.author | Moon, Kyung Jin | - |
dc.contributor.author | Chun, Kyung-Hee | - |
dc.contributor.author | Yoon, Sung-Soo | - |
dc.contributor.author | Park, Seonyang | - |
dc.contributor.author | Lee, Jong Seok | - |
dc.contributor.author | Kong, Sun-Young | - |
dc.date.accessioned | 2012-05-29T06:31:46Z | - |
dc.date.available | 2012-05-29T06:31:46Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | LEUKEMIA & LYMPHOMA; Vol.51 1; 132-145 | ko_KR |
dc.identifier.issn | 1042-8194 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76554 | - |
dc.description.abstract | Novel phytosphingosine derivatives have been developed based on the inhibition of sphingosine kinase, which has been implicated in cell growth and inhibition of ceramide-mediated apoptosis. This study evaluated the cytotoxic effects and underlying mechanisms of action of novel phytosphingosine derivatives, including N-monomethylphytosphingosine (MMPH) and N,N-dimethylphytosphingosine (DMPH) and the pegylated forms MMPH-PEG and DMPH-PEG, in human leukemia HL60 cells. In viability and proliferation assays using WST-1, all four drugs induced suppression of cell growth and viability in a concentration-dependent manner. Among them, DMPH had the highest antileukemic activity and induced apoptosis via caspase-8, caspase-3, and caspase-9 activation. The apoptotic effect was also associated with Fas/FasL upregulation, Bid cleavage, Bcl-2 downregulation, Bax upregulation, mitochondrial membrane depolarization, and cytochrome c release. DMPH decreased the phosphorylation of ERK and inhibited daunorubicin-induced ERK activation. Furthermore, DMPH displayed synergistic cytotoxicity with daunorubicin in a sequence-dependent manner. Our findings indicate that DMPH has potential as an effective cytotoxic agent for leukemia. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | TAYLOR & FRANCIS LTD | ko_KR |
dc.subject | N-monomethylphytosphingosine | ko_KR |
dc.subject | N,N-dimethylphytosphingosine | ko_KR |
dc.subject | leukemia | ko_KR |
dc.subject | daunorubicin | ko_KR |
dc.subject | cytotoxicity | ko_KR |
dc.subject | apoptosis | ko_KR |
dc.title | Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and N-monomethylphytosphingosine, in human leukemia cell line HL60 | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박숙련 | - |
dc.contributor.AlternativeAuthor | 조효진 | - |
dc.contributor.AlternativeAuthor | 문경진 | - |
dc.contributor.AlternativeAuthor | 전경희 | - |
dc.contributor.AlternativeAuthor | 공선영 | - |
dc.contributor.AlternativeAuthor | 윤성수 | - |
dc.contributor.AlternativeAuthor | 이종석 | - |
dc.contributor.AlternativeAuthor | 박선양 | - |
dc.identifier.doi | 10.3109/10428190903383419 | - |
dc.citation.journaltitle | LEUKEMIA & LYMPHOMA | - |
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dc.description.tc | 2 | - |
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