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Role of autophagy in diabetes and mitochondria

Cited 61 time in Web of Science Cited 63 time in Scopus
Authors
Jung, Hye Seung; Lee, Myung-Shik
Issue Date
2010
Publisher
WILEY-BLACKWELL
Citation
MITOCHONDRIAL ANNALS OF THE NEW YORK ACADEMY OF SCIENCES; Vol.1201 ; 79-83
Keywords
autophagyinsulin resistancepancreatic β-cellmitochondriadiabetes
Abstract
Type 2 diabetes mellitus is characterized by insulin resistance and failure of pancreatic beta-cells producing insulin. Mitochondrial dysfunction may play a role in both processes of diabetes. Autophagy maintains cellular homeostasis through degradation and recycling of organelles such as mitochondria. As dysfunctional mitochondria are the main organelles removed by autophagy, we studied the role of autophagy in diabetes using mice with beta-cell specific deletion of the Atg7 gene. Atg7-mutant mice showed reduction in beta-cell mass and pancreatic insulin content. Electron microscopy showed swollen mitochondria and other ultrastructural changes in autophagy-deficient beta-cells. Insulin secretory function ex vivo was also impaired. As a result, Atg7-mutant mice showed hypoinsulinemia and hyperglycemia. These results suggest that autophagy is necessary to maintain structure, mass, and function of beta-cells. Besides its effect on beta-cells, autophagy may affect insulin sensitivity because mitochondrial dysfunction has been implicated in insulin resistance and autophagy is involved in the maintenance of the organelles. Furthermore, since aging is associated with impaired glucose tolerance, decline of autophagic activity may be involved in age-associated reduction of glucose tolerance.
ISSN
0077-8923
Language
English
URI
http://hdl.handle.net/10371/76565
DOI
https://doi.org/10.1111/j.1749-6632.2010.05614.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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