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Polymorphisms in KCNQ1 Are Associated with Gestational Diabetes in a Korean Population

Cited 14 time in Web of Science Cited 16 time in Scopus
Authors
Kwak, Soo Heon; Kim, Tae Hyuk; Cho, Young Min; Choi, Sung Hee; Park, Kyong Soo; Jang, Hak C.
Issue Date
2010
Publisher
KARGER
Citation
HORMONE RESEARCH IN PAEDIATRICS; Vol.74 5; 333-338
Keywords
Gestational diabetes mellitusKCNQ1Polymorphism
Abstract
Background: Recent genome-wide association studies in East Asians have identified polymorphisms in KCNQ1 as new type 2 diabetes risk variants. The aim of this study was to investigate whether variants in KCNQ1 are associated with development of gestational diabetes mellitus (GDM) and measures of oral glucose tolerance test (OGTT) at the time of diagnosis of GDM. Methods: Three candidate single nucleotide polymorphisms (rs2074196, rs2237892, and rs2237895) were genotyped in 869 Korean GDM women and 632 nondiabetic control subjects. Insulin resistance was estimated by homeostasis model assessment and pancreatic beta-cell function by the insulinogenic index at 1 h. Results: rs2074196 and rs2237892 were associated with the risk of GDM (OR 1.17, 95% CI 1.01-1.36, p = 0.039; OR 1.24, 95% CI 1.07-1.45, p = 0.0049). Furthermore, rs2237892 and rs2237895 were nominally associated with a decreased insulinogenic index at the time of GDM diagnosis (p = 0.025 and p = 0.037), whereas no association was observed with measures of insulin resistance. Conclusions: The single nucleotide polymorphisms in KCNQ1 showed a significant association with GDM in the Korean population. Although the mechanism is not yet clear, it could be possible that variants in KCNQ1 confer a risk for GDM by altering pancreatic beta-cell function. Copyright (C) 2010 S. Karger AG, Basel
ISSN
1663-2818
Language
English
URI
http://hdl.handle.net/10371/76566
DOI
https://doi.org/10.1159/000313918
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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