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A Relationship Between Alzheimer`s Disease and Type 2 Diabetes Mellitus Through the Measurement of Serum Amyloid-beta Autoantibodies

Cited 13 time in Web of Science Cited 17 time in Scopus
Authors
Kim, Insub; Lee, Junhee; Hong, Hyun Joo; Jung, Eun Sun; Jeong, In Kyong; So, Insuk; Mook-Jung, Inhee; Park, Kyong Soo; Cho, Young Min; Ku, Yun Hyi
Issue Date
2010
Publisher
IOS PRESS
Citation
JOURNAL OF ALZHEIMERS DISEASE; Vol.19 4; 1371-1376
Keywords
A beta Autoantibodytype 2 diabetes mellituscholesterolbiomarkerAlzheimer`s disease
Abstract
Increasing evidence suggests that type 2 diabetes mellitus (T2DM) is strongly correlated with Alzheimer`s disease (AD). To examine the relationship between T2DM and AD, autoantibodies against amyloid-A beta were measured in the serum of T2DM patients and age-matched controls. Levels of A beta autoantibody were measured by ELISA in serum samples of T2DM patients (n = 92) and age-matched control group (n = 106). A beta autoantibody levels were increased in T2DM compared with age-matched controls by 45.4 +/- 8.1% (p < 0.001). Females had higher A beta autoantibody levels than males in both T2DM and control group. A beta autoantibody levels in the T2DM group were positively correlated with the levels of cholesterol (p = 0.011), low density lipoprotein cholesterol (p = 0.020), and triglycerides (p = 0.039). In conclusion, the level of A beta autoantibody is dramatically elevated in patient serum of T2DM, and, as such, might be used as a possible biomarker for T2DM.
ISSN
1387-2877
Language
English
URI
http://hdl.handle.net/10371/76575
DOI
https://doi.org/10.3233/JAD-2010-1332
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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