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Omacor (R), n-3 polyunsaturated fatty acid, attenuated albuminuria and renal dysfunction with decrease of SREBP-1 expression and triglyceride amount in the kidney of type II diabetic animals
DC Field | Value | Language |
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dc.contributor.author | Chin, Ho Jun | - |
dc.contributor.author | Fu, Yan Yan | - |
dc.contributor.author | Ahn, Jeong Myung | - |
dc.contributor.author | Na, Ki Young | - |
dc.contributor.author | Kim, Suhnggwon | - |
dc.contributor.author | Chae, Dong-Wan | - |
dc.contributor.author | Kim, Yon Su | - |
dc.date.accessioned | 2012-05-30T01:43:55Z | - |
dc.date.available | 2012-05-30T01:43:55Z | - |
dc.date.issued | 2010-05 | - |
dc.identifier.citation | NEPHROLOGY DIALYSIS TRANSPLANTATION; Vol.25 5; 1450-1457 | ko_KR |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76604 | - |
dc.description.abstract | Methods. We gavaged Omacor (R), composed of docosahexaenoic acid and eicosapentaenoic acid, to db/db mice for 2 weeks (0.2 g/100 g/day). We measured the markers of renal function, triglyceride amount and expressions of SREBP-1, liver X-activated receptor alpha (LXR alpha), collagen IV and TGF beta-1 in kidney lysate, and performed immunohistochemical staining for SREBP-1, desmin and WT-1 in the renal sections. We measured collagen IV in primary mesangial cells cultured with high glucose media (25 mM), both with and without a transient transfection of small interfering RNA (siRNA) SREBP-1. Results. Omacor (R) decreased the concentration of serum free fatty acid, and the amount of renal triglyceride, which was associated with decreased expression of SREBP-1 in the kidney, albuminuria and renal dysfunction in db/db mice. Omacor (R) attenuated the expansion of mesangial matrix and the expression of desmin, preserved the WT-1 positive cells, and inhibited the phosphorylation of nuclear factor kappa B in renal tissue. In mesangial cells cultured in high glucose media, the suppression of SREBP-1 expression decreased the collagen IV in the cells. Conclusions. Our study results demonstrated that n-3 PUFA prevented renal progression with attenuation of SREBP-1 and reduction of triglyceride in the diabetic kidney. This suggests that the regulation of dyslipidemic signals in the kidney could be a possible mechanism by which PUFA preserves renal function in the diabetic condition. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | OXFORD UNIV PRESS | ko_KR |
dc.subject | diabetic nephropathy | ko_KR |
dc.subject | n-3 PUFA | ko_KR |
dc.subject | SREBP-1 | ko_KR |
dc.subject | hypertriglyceridaemia | ko_KR |
dc.title | Omacor (R), n-3 polyunsaturated fatty acid, attenuated albuminuria and renal dysfunction with decrease of SREBP-1 expression and triglyceride amount in the kidney of type II diabetic animals | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 진호준 | - |
dc.contributor.AlternativeAuthor | 안정명 | - |
dc.contributor.AlternativeAuthor | 나기영 | - |
dc.contributor.AlternativeAuthor | 김연수 | - |
dc.contributor.AlternativeAuthor | 김성권 | - |
dc.contributor.AlternativeAuthor | 채동완 | - |
dc.identifier.doi | 10.1093/ndt/gfp695 | - |
dc.citation.journaltitle | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.description.citedreference | Cruz-Garcia L, 2009, COMP BIOCHEM PHYS B, V153, P81, DOI 10.1016/j.cbpb.2009.02.001 | - |
dc.description.citedreference | Garman JH, 2009, AM J PHYSIOL-RENAL, V296, pF306, DOI 10.1152/ajprenal.90326.2008 | - |
dc.description.citedreference | Ishigaki N, 2007, BIOCHEM BIOPH RES CO, V364, P502, DOI 10.1016/j.bbrc.2007.10.038 | - |
dc.description.citedreference | Rossary A, 2007, BIOCHEM J, V406, P77, DOI 10.1042/BJ20061009 | - |
dc.description.citedreference | Rossary A, 2007, ANN BIOL CLIN-PARIS, V65, P33 | - |
dc.description.citedreference | Proctor G, 2006, DIABETES, V55, P2502, DOI 10.2337/db05-0603 | - |
dc.description.citedreference | Hagiwara S, 2006, NEPHROL DIAL TRANSPL, V21, P605, DOI 10.1093/ndt/gfi208 | - |
dc.description.citedreference | Botolin D, 2006, J LIPID RES, V47, P181, DOI 10.1194/jlr.M500365-JLR200 | - |
dc.description.citedreference | DAVIDSON MH, 2006, AM J CARDIOL, V98, P27 | - |
dc.description.citedreference | Jiang T, 2005, J BIOL CHEM, V280, P32317, DOI 10.1074/jbc.M500801200 | - |
dc.description.citedreference | Wang ZW, 2005, DIABETES, V54, P2328, DOI 10.2337/diabetes.54.8.2328 | - |
dc.description.citedreference | Mathai ML, 2004, OBES RES, V12, P1886 | - |
dc.description.citedreference | Mishra A, 2004, ARTERIOSCL THROM VAS, V24, P1621, DOI 10.1161/01.ATV.0000137191.02577.86 | - |
dc.description.citedreference | Ukropec J, 2003, LIPIDS, V38, P1023 | - |
dc.description.citedreference | Kim SY, 2003, NEPHROLOGY, V8, pS2 | - |
dc.description.citedreference | Yoshikawa T, 2003, MOL ENDOCRINOL, V17, P1240, DOI 10.1210/me.2002-0190 | - |
dc.description.citedreference | Pawar A, 2002, J BIOL CHEM, V277, P39243, DOI 10.1074/jbc.M206170200 | - |
dc.description.citedreference | Peyron-Caso E, 2002, J NUTR, V132, P2235 | - |
dc.description.citedreference | Wang HQ, 2002, AM J PHYSIOL-ENDOC M, V282, pE1352, DOI 10.1152/ajpendo.00230.2001 | - |
dc.description.citedreference | Sun LJ, 2002, J BIOL CHEM, V277, P18919, DOI 10.1074/jbc.M110650200 | - |
dc.description.citedreference | Zheng F, 2002, AM J PHYSIOL-RENAL, V282, pF639, DOI 10.1152/ajprenal.00189.2001 | - |
dc.description.citedreference | Becard D, 2001, DIABETES, V50, P2425 | - |
dc.description.citedreference | Ou JF, 2001, P NATL ACAD SCI USA, V98, P6027 | - |
dc.description.citedreference | Mollsten AV, 2001, DIABETES CARE, V24, P805, DOI 10.2337/diacare.24.5.805 | - |
dc.description.citedreference | Xu J, 2001, J BIOL CHEM, V276, P9800 | - |
dc.description.citedreference | Raptis AE, 2001, EXP CLIN ENDOCR DIAB, V109, pS424 | - |
dc.description.citedreference | Joles JA, 2000, J AM SOC NEPHROL, V11, P669 | - |
dc.description.citedreference | KEANE WF, 2000, KIDNEY INT S, V75, pS27 | - |
dc.description.citedreference | Yahagi N, 1999, J BIOL CHEM, V274, P35840, DOI 10.1074/jbc.274.50.35840 | - |
dc.description.citedreference | Desvergne B, 1999, ENDOCR REV, V20, P649 | - |
dc.description.citedreference | Worgall TS, 1998, J BIOL CHEM, V273, P25537 | - |
dc.description.citedreference | Martin T, 1997, EUR J IMMUNOL, V27, P1091 | - |
dc.description.citedreference | ODA H, 1997, KIDNEY INT S, V62, pS36 | - |
dc.description.citedreference | Lavaud S, 1996, J AM SOC NEPHROL, V7, P2604 | - |
dc.description.citedreference | SHIMIZU H, 1995, DIABETES RES CLIN PR, V28, P35 | - |
dc.description.citedreference | FUJIKAWA M, 1994, J NUTR SCI VITAMINOL, V40, P49 | - |
dc.description.citedreference | FURUTA T, 1993, AM J KIDNEY DIS, V21, P480 | - |
dc.description.citedreference | BARCELLI UO, 1990, AM J KIDNEY DIS, V16, P244 | - |
dc.description.citedreference | SINHA AK, 1990, J LIPID RES, V31, P1219 | - |
dc.description.citedreference | JENSEN T, 1989, NEW ENGL J MED, V321, P1572 | - |
dc.description.citedreference | KASISKE BL, 1988, KIDNEY INT, V33, P667 | - |
dc.description.citedreference | BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911 | - |
dc.description.tc | 5 | - |
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