S-Space College of Medicine/School of Medicine (의과대학/대학원) Pathology (병리학전공) Journal Papers (저널논문_병리학전공)
Cyclooxygenase-2 Expression in Cervical Intraepithelial Neoplasia
- Kim, Kidong; Jeon, Yong-Tark; Park, In-Ae; Kim, Jae Weon; Kang, Soon-Beom; Song, Yong-Sang; Lee, Hyo-Pyo; Park, Noh-Hyun
- Issue Date
- BLACKWELL PUBLISHING
- Annals of the New York Academy of Sciences; Vol.1171 ; 111-115
- cyclooxygenase-2; cervical intraepithelial neoplasia (CIN); menopause; stromal cells; epithelium; age factors
- To evaluate the role of cyclooxygenase (COX)-2 during cervical carcinogenesis, we investigated COX-2 expression in the dysplastic epithelium and stromal cells of cervical intraepithelial neoplasia (CIN). Immunohistochemical analysis with COX-2 antibody was performed on 148 paraffin-embedded tissue specimens of patients who were diagnosed as CIN in our institute. COX-2 expression was evaluated separately in the dysplastic epithelium and stromal cells of CIN. The relationships between COX-2 expression and clinicopathologic variables were examined. For the dysplastic epithelium, COX-2 expression was negative in 137 (92.6%) and positive in 11 (7.4%) specimens. For the stromal cells, COX-2 expression was negative in all specimens. The COX-2 expression in dysplastic epithelium was higher in older (P = 0.038) or postmenopausal (P = 0.025) women. In conclusion, COX-2 expression was observed only in the dysplastic epithelium but not in the stromal cells of CIN. The COX-2 expression in dysplastic epithelium was associated with age and menopausal status.
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