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Cyclooxygenase-2 Expression in Cervical Intraepithelial Neoplasia

Cited 6 time in Web of Science Cited 4 time in Scopus
Authors
Kim, Kidong; Jeon, Yong-Tark; Park, In-Ae; Kim, Jae Weon; Kang, Soon-Beom; Song, Yong-Sang; Lee, Hyo-Pyo; Park, Noh-Hyun
Issue Date
2009
Publisher
BLACKWELL PUBLISHING
Citation
Annals of the New York Academy of Sciences; Vol.1171 ; 111-115
Keywords
cyclooxygenase-2cervical intraepithelial neoplasia (CIN)menopausestromal cellsepitheliumage factors
Abstract
To evaluate the role of cyclooxygenase (COX)-2 during cervical carcinogenesis, we investigated COX-2 expression in the dysplastic epithelium and stromal cells of cervical intraepithelial neoplasia (CIN). Immunohistochemical analysis with COX-2 antibody was performed on 148 paraffin-embedded tissue specimens of patients who were diagnosed as CIN in our institute. COX-2 expression was evaluated separately in the dysplastic epithelium and stromal cells of CIN. The relationships between COX-2 expression and clinicopathologic variables were examined. For the dysplastic epithelium, COX-2 expression was negative in 137 (92.6%) and positive in 11 (7.4%) specimens. For the stromal cells, COX-2 expression was negative in all specimens. The COX-2 expression in dysplastic epithelium was higher in older (P = 0.038) or postmenopausal (P = 0.025) women. In conclusion, COX-2 expression was observed only in the dysplastic epithelium but not in the stromal cells of CIN. The COX-2 expression in dysplastic epithelium was associated with age and menopausal status.
ISSN
0077-8923
Language
English
URI
http://hdl.handle.net/10371/76620
DOI
https://doi.org/10.1111/j.1749-6632.2009.04724.x
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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