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(18)F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma
DC Field | Value | Language |
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dc.contributor.author | Lee, Jeong Won | - |
dc.contributor.author | Kang, Keon Wook | - |
dc.contributor.author | Park, Sung-Hye | - |
dc.contributor.author | Lee, Sang Mi | - |
dc.contributor.author | Chung, June-Key | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.contributor.author | Lee, Myung Chul | - |
dc.contributor.author | Paeng, Jin Chul | - |
dc.date.accessioned | 2012-05-30T06:52:55Z | - |
dc.date.available | 2012-05-30T06:52:55Z | - |
dc.date.issued | 2009-10 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING; Vol.36 10; 1574-1582 | ko_KR |
dc.identifier.issn | 1619-7070 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76621 | - |
dc.description.abstract | Purpose The purpose of this study was to investigate the role of (18)F-fluorodeoxyglucose (FDG) PET in detecting high-grade meningioma and predicting the recurrence in patients with meningioma after surgical resection. Methods Fifty-nine patients (27 men and 32 women) with intracranial meningioma who underwent preoperative FDG PET and subsequent surgical resection were enrolled. All patients underwent clinical follow-up for tumor recurrence with a mean duration of 34 +/- 20 months. The tumor to gray matter ratio (TGR) of FDG uptake was calculated and a receiver-operating characteristic (ROC) curve of the TGR was drawn to determine the cutoff value of the TGR for detection of high-grade meningioma. Further, univariate analysis with the log-rank test was performed to assess the predictive factors of meningioma recurrence. Results The TGR in high-grade meningioma (WHO grade II and III) was significantly higher than that in low-grade ones (WHO grade I) (p = 0.002) and significantly correlated with the MIB-1 labeling index (r = 0.338, p = 0.009) and mitotic count of the tumor (r = 0.284, p = 0.03). The ROC analysis revealed that the TGR of 1.0 was the best cutoff value for detecting high-grade meningioma with a sensitivity of 43%, specificity of 95%, and accuracy of 81%. Of 59 patients, 5 (9%) had a recurrent event. In the log-rank test, the TGR, MIB-1 labeling index, presence of brain invasion, and WHO grade were significantly associated with tumor recurrence. The cumulative recurrence-free survival rate of patients with a TGR of 1.0 or less was significantly higher than that of patients with a TGR of more than 1.0 (p = 0.0003) Conclusion FDG uptake in meningioma was the significant predictive factor of tumor recurrence and significantly correlated with the proliferative potential of the tumor. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPRINGER | ko_KR |
dc.subject | Meningioma | ko_KR |
dc.subject | Positron emission tomography (PET) | ko_KR |
dc.subject | (18)F-fluorodeoxyglucose (FDG) | ko_KR |
dc.subject | Prognosis | ko_KR |
dc.subject | Recurrence | ko_KR |
dc.title | (18)F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이정원 | - |
dc.contributor.AlternativeAuthor | 강건욱 | - |
dc.contributor.AlternativeAuthor | 박성혜 | - |
dc.contributor.AlternativeAuthor | 이상미 | - |
dc.contributor.AlternativeAuthor | 팽진철 | - |
dc.contributor.AlternativeAuthor | 정준기 | - |
dc.contributor.AlternativeAuthor | 이명철 | - |
dc.contributor.AlternativeAuthor | 이동수 | - |
dc.identifier.doi | 10.1007/s00259-009-1133-x | - |
dc.citation.journaltitle | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
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dc.description.tc | 5 | - |
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