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Increased K-ras mutation and expression of S100A4 and MUC2 protein in the malignant intraductal papillary mucinous tumor of the pancreas

Cited 19 time in Web of Science Cited 22 time in Scopus
Authors
Jang, Jin-Young; Park, Yoon-Chan; Song, Yoon Sup; Lee, Seung Eun; Lim, Chang-Sup; Kim, Woo Ho; Kim, Sun-Whe; Lee, Hee Eun; Hwang, Dae Wook
Issue Date
2009-09
Publisher
SPRINGER TOKYO
Citation
JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY; Vol.16 5; 668-674
Keywords
Intraductal papillary mucinous tumor of pancreasK-ras mutationMalignancyMUC
Abstract
The purpose of this study was to document the biological changes during the progression of intraductal papillary mucinous neoplasm of the pancreas (IPMN) and to identify biological markers capable of differentiating benign and malignant IPMN. Forty-one patients with IPMN who underwent resection between 1994 and 2003 were enrolled in this study. The paraffin-embedded tumors from 27 with benign IPMNs and from 14 with IPMCs were subjected to immunohistochemical staining and DNA extraction. Direct DNA sequencing analysis for K-ras mutation and immunohistochemical staining using 17 biological markers was performed. K-ras mutations at codon 12 and 13 were detected in 13 of 37 (38.2%) of the IPMNs: in 5 of 24 (20.8%) of benign IPMNs, and in 8 of 13 (61.5%) of malignant IPMNs (p = 0.028). The expression of S100A4 and MUC2 were increased in malignant IPMNs. S100A4 was expressed in 2 (7.4%) of 27 benign IPMNs, and 6 (42.9%) of 14 malignant IPMNs (p = 0.007). MUC2 was expressed in 2 (7.4%) benign IPMNs, and in 9 (64.3%) malignant IPMNs (p < 0.001). K-ras mutation and the expression of S100A4 and MUC2 (especially in intestinal subtype) were found to be related to malignancy in IPMN, and may be useful for the diagnosis and for assessing the biological behavior of IPMN.
ISSN
0944-1166
Language
English
URI
http://hdl.handle.net/10371/76628
DOI
https://doi.org/10.1007/s00534-009-0105-7
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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