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PRESENCE OF HPV TYPE 6 IN DYSPLASIA AND CARCINOMA ARISING FROM RECURRENT RESPIRATORY PAPILLOMATOSIS

Cited 16 time in Web of Science Cited 21 time in Scopus
Authors
Jeong, Woo-Jin; Park, Seok-Woo; Shin, Miwha; Lee, You Jeong; Jung, Young Ho; Kwon, Tack-Kyun; Kim, Kwang Hyun; Sung, Myung-Whun; Song, Yong-Sang; Hah, J. Hun; Jeon, Yoon Kyung
Issue Date
2009-08
Publisher
JOHN WILEY & SONS INC
Citation
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; Vol.31 8; 1095-1101
Keywords
recurrent respiratory papillomatosiscarcinomahuman papillomavirustumor virus infectionsmalignant transformation
Abstract
Background. We collected rare cases of recurrent respiratory papillomatosis (RRP) undergoing malignant transformation. We sought to identify human papillomavirus (HPV) subtypes in areas of papilloma, dysplasia, and carcinoma and investigate thve pattern of protein overexpression. Methods. Three patients whose disease underwent malignant transformation from RRP to carcinoma were subjected to this study, Morphologically distinct areas in the pathology specimen of each patient were diagnosed as papilloma, dysplasia. and carcinoma. Each lesion was separately obtained by laser capture microdissection and was PCR amplified for the presence of HPV. A DNA chip was used to determine the type of HPV in each area. Immunohistochemistry for p53, Ki-67, and pRb was performed. Results. HPV type 6 was present in all specimens tested positive, Expression of p53 and Ki-67 increased with increasing severity of dysplastic change. Conclusion. Although HPV type 11 is most frequently associated with malignant change of RRP. HPV type 6 may also contribute to play an equally important role in RRP carcinogenesis. (C) 2008 Wiley Periodicals, Inc. Head Neck 31: 1095-1101, 2009
ISSN
1043-3074
Language
English
URI
http://hdl.handle.net/10371/76632
DOI
https://doi.org/10.1002/hed.20998
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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