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The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury
DC Field | Value | Language |
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dc.contributor.author | Choi, Won-Il | - |
dc.contributor.author | Kwon, Kun Young | - |
dc.contributor.author | Seo, Jeong Wook | - |
dc.contributor.author | Beagle, John | - |
dc.contributor.author | Hales, Charles A. | - |
dc.contributor.author | Quinn, Deborah A. | - |
dc.date.accessioned | 2012-05-31T00:42:40Z | - |
dc.date.available | 2012-05-31T00:42:40Z | - |
dc.date.issued | 2009-06-01 | - |
dc.identifier.citation | BMC INFECTIOUS DISEASES; Vol.9 ; 80- | ko_KR |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76637 | - |
dc.description.abstract | Background: Acute kidney injury frequently accompanies sepsis. Endotoxin is known to reduce tissue levels of cAMP and low levels of cAMP have been associated with renal injury. We, therefore, hypothesized that endotoxin induced renal injury by activating phosphodiesterase 3 (PDE3) which metabolizes cAMP and that amrinone an inhibitor of PDE3 would prevent the renal injury. Methods: Animals were divided into three groups (n = 7/group): 1) Control (0.9% NaCl infusion without LPS); 2) LPS (0.9% NaCl infusion with LPS); 3) Amrinone+LPS (Amrinone infusion with LPS). Either lipopolysaccharide (LPS) or vehicle was injected via the jugular vein and the rats followed for 3 hours. We explored the expression of PDE3 isoenzymes and the concentrations of cAMP in the tissue. Results: The PDE3B gene but not PDE3A was upregulated in the kidney of LPS group. Immunohistochemistry also showed that PDE3B was expressed in the distal tubule in the controls and LPS caused PDE3B expression in the proximal as well. However, PDE3A was not expressed in the kidney either in the control or LPS treated groups. Tissue level of cAMP was decreased after LPS and was associated with an increase in blood urea nitrogen, creatinine, ultrastructural proximal tubular changes, and expression of inducible nitric oxide synthase (iNOS) in the endotoxemic kidney. In septic animals the phosphodiesterase 3 inhibitor, amrinone, preserved the tissue cAMP level, renal structural changes, and attenuated the increased blood urea nitrogen, creatinine, and iNOS expression in the kidney. Conclusion: These findings suggest a significant role for PDE3B as an important mediator of LPS-induced acute kidney injury. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BIOMED CENTRAL LTD | ko_KR |
dc.title | The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 최원일 | - |
dc.contributor.AlternativeAuthor | 권군용 | - |
dc.contributor.AlternativeAuthor | 서정욱 | - |
dc.identifier.doi | 10.1186/1471-2334-9-80 | - |
dc.citation.journaltitle | BMC INFECTIOUS DISEASES | - |
dc.description.citedreference | Piccoli C, 2008, STEM CELLS, V26, P2843, DOI 10.1634/stemcells.2007-0885 | - |
dc.description.citedreference | Wu XY, 2007, AM J PHYSIOL-RENAL, V293, pF1262, DOI 10.1152/ajprenal.00445.2006 | - |
dc.description.citedreference | Gupta A, 2007, AM J PHYSIOL-RENAL, V293, pF245, DOI 10.1152/ajprenal.00477.2006 | - |
dc.description.citedreference | Wu LP, 2007, AM J PHYSIOL-RENAL, V292, pF261, DOI 10.1152/ajprenal.00263.2006 | - |
dc.description.citedreference | Heemskerk S, 2006, CLIN J AM SOC NEPHRO, V1, P853, DOI 10.2215/CJN.00490206 | - |
dc.description.citedreference | Zager RA, 2006, AM J PHYSIOL-RENAL, V290, pF1453, DOI 10.1152/ajprenal.00485.2005 | - |
dc.description.citedreference | Sternberg EM, 2006, NAT REV IMMUNOL, V6, P318, DOI 10.1038/nri1810 | - |
dc.description.citedreference | Kwon KY, 2006, TOXICOLOGY, V218, P197, DOI 10.1016/j.tox.2005.10.013 | - |
dc.description.citedreference | Suzuki H, 2006, BIOL PHARM BULL, V29, P131 | - |
dc.description.citedreference | Tiwari MM, 2005, AM J PHYSIOL-RENAL, V289, pF1324, DOI 10.1152/ajprenal.00124.2005 | - |
dc.description.citedreference | Mizutani A, 2005, SHOCK, V24, P281, DOI 10.1097/01.shk.0000175555.95676.34 | - |
dc.description.citedreference | Ympa YP, 2005, AM J MED, V118, P827, DOI 10.1016/j.amjmed.2005.01.069 | - |
dc.description.citedreference | Wang W, 2005, AM J PHYSIOL-RENAL, V288, pF997, DOI 10.1152/ajprenal.00130.2004 | - |
dc.description.citedreference | Asakura H, 2005, J THROMB HAEMOST, V3, P1050 | - |
dc.description.citedreference | Kadkhodaee M, 2004, CLIN EXP PHARMACOL P, V31, P842 | - |
dc.description.citedreference | Misharin AV, 2004, B EXP BIOL MED+, V138, P452 | - |
dc.description.citedreference | Schrier RW, 2004, NEW ENGL J MED, V351, P159, DOI 10.1056/NEJMra032401 | - |
dc.description.citedreference | Lee JH, 2004, J IMMUNOL, V172, P608 | - |
dc.description.citedreference | Murray F, 2002, BRIT J PHARMACOL, V137, P1187, DOI 10.1038/sj.bjp.0704984 | - |
dc.description.citedreference | Harndahl L, 2002, J BIOL CHEM, V277, P37446, DOI 10.1074/jbc.M205401200 | - |
dc.description.citedreference | Jonassen TEN, 2002, J PHARMACOL EXP THER, V303, P364, DOI 10.1124/jpet.102.036194 | - |
dc.description.citedreference | Purswani MU, 2002, J ANTIMICROB CHEMOTH, V50, P51, DOI 10.1093/jac/dkf091 | - |
dc.description.citedreference | Karabulut R, 2002, UROL RES, V30, P164, DOI 10.1007/s00240-002-0256-3 | - |
dc.description.citedreference | Kobayashi T, 2002, J HEPATOL, V37, P31 | - |
dc.description.citedreference | Dunkerley HA, 2002, MOL PHARMACOL, V61, P1033 | - |
dc.description.citedreference | Chatterjee PK, 2002, KIDNEY INT, V61, P862 | - |
dc.description.citedreference | CHANANI NK, 2002, CIRCULATION S1, V106, P284 | - |
dc.description.citedreference | Landry DW, 2001, NEW ENGL J MED, V345, P588 | - |
dc.description.citedreference | Hickey MJ, 2001, CLIN SCI, V100, P1 | - |
dc.description.citedreference | Elenkov IJ, 2000, PHARMACOL REV, V52, P595 | - |
dc.description.citedreference | Goujon JM, 1999, J SURG RES, V82, P228 | - |
dc.description.citedreference | Dousa TP, 1999, KIDNEY INT, V55, P29 | - |
dc.description.citedreference | Pahan K, 1997, J BIOL CHEM, V272, P7786 | - |
dc.description.citedreference | Degerman E, 1997, J BIOL CHEM, V272, P6823 | - |
dc.description.citedreference | Tomita I, 1996, TRANSPLANTATION, V62, P167 | - |
dc.description.citedreference | KANG YH, 1995, SHOCK, V4, P441 | - |
dc.description.citedreference | REINHARDT RR, 1995, J CLIN INVEST, V95, P1528 | - |
dc.description.citedreference | RANGELFRAUSTO MS, 1995, JAMA-J AM MED ASSOC, V273, P117 | - |
dc.description.citedreference | OGAWA S, 1992, AM J PHYSIOL, V262, pC546 | - |
dc.description.citedreference | SKOYLES JR, 1992, BRIT J ANAESTH, V68, P293 | - |
dc.description.citedreference | ROMANI A, 1991, J BIOL CHEM, V266, P24376 | - |
dc.description.citedreference | OHLSSON K, 1990, NATURE, V348, P550 | - |
dc.description.citedreference | COHEN JJ, 1990, KIDNEY INT, V37, P1219 | - |
dc.description.citedreference | CHURCHILL PC, 1987, AM J PHYSIOL, V253, pF244 | - |
dc.description.citedreference | KIKERI D, 1986, AM J PHYSIOL, V250, P1098 | - |
dc.description.citedreference | MANDAL AK, 1982, AM J KIDNEY DIS, V2, P363 | - |
dc.description.citedreference | BENOTTI JR, 1978, NEW ENGL J MED, V299, P1373 | - |
dc.description.tc | 0 | - |
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