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CD24, a Novel Cancer Biomarker, Predicting Disease-Free Survival of Non-small Cell Lung Carcinomas A Retrospective Study of Prognostic Factor Analysis from the Viewpoint of Forthcoming (Seventh) New TNM Classification
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Choe, Gheeyoung | - |
dc.contributor.author | Jheon, Sanghoon | - |
dc.contributor.author | Sung, Sook-Whan | - |
dc.contributor.author | Chung, Jin-Haeng | - |
dc.contributor.author | Lee, Choon-Taek | - |
dc.date.accessioned | 2012-05-31T05:21:02Z | - |
dc.date.available | 2012-05-31T05:21:02Z | - |
dc.date.issued | 2010-05 | - |
dc.identifier.citation | JOURNAL OF THORACIC ONCOLOGY; Vol.5 5; 649-657 | ko_KR |
dc.identifier.issn | 1556-0864 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76673 | - |
dc.description.abstract | Introduction: Metastasis-associated protein CD24 has been identified as a new prognostic factor and stem cell marker in the human neoplasm. However, the importance of the CD24 in non-small cell lung carcinomas (NSCLCs) has not been elucidated well. Methods: We evaluated CD24 expression in 267 consecutive cases of NSCLC by immunohistochemistry using a tissue microarray technique and correlated with clinicopathologic parameters including forthcoming (seventh) new tumor node metastasis classification. Results: CD24-high expression was demonstrated in 87 of 267 (33%) and was associated with adenocarcinoma (ADC) histology than in squamous cell carcinoma histology (64 of 165 [39%] vs. 20 of 88 [23%]; p = 0.023). Patients with CD24-high tumors tended to have a higher risk of disease progression (p < 0.001) and cancer-related death (p = 0.002). Multivariate analysis proved CD24-high expression as independent prognostic factors of disease progression and cancer-related death (p = 0.002, hazard ratio = 1.78, 95% confidence interval = 1.23-2.58 and p = 0.017, hazard ratio = 1.93, 95% confidence interval = 1.13-3.31). CD24-high expression had a tendency to correlate with new pathologic stage (p-stage) (p = 0.089) rather than old p-stage (p = 0.253). Performance status and new p-stage, regardless of the tumor histology, were identified as consistent independent prognostic factors of disease progression and cancer-related death. However, age was related to a significantly shorter cancer-specific survival in ADC only. Conclusions: CD24 expression in NSCLC is associated with ADC histology and disease progression and cancer-related death, indicative of aggressive tumor behavior. Performance status and new p-stage, to a lesser extent, age correlated with progression-free survival and cancer-specific survival, regardless of tumor histology. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | ko_KR |
dc.subject | Carcinoma | ko_KR |
dc.subject | CD24 | ko_KR |
dc.subject | Prognostic factors | ko_KR |
dc.subject | Pathologic stage | ko_KR |
dc.subject | Prognosis | ko_KR |
dc.subject | Non-small cell lung | ko_KR |
dc.subject | Immunohistochemistry | ko_KR |
dc.title | CD24, a Novel Cancer Biomarker, Predicting Disease-Free Survival of Non-small Cell Lung Carcinomas A Retrospective Study of Prognostic Factor Analysis from the Viewpoint of Forthcoming (Seventh) New TNM Classification | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이현주 | - |
dc.contributor.AlternativeAuthor | 최기영 | - |
dc.contributor.AlternativeAuthor | 전상훈 | - |
dc.contributor.AlternativeAuthor | 성숙환 | - |
dc.contributor.AlternativeAuthor | 이춘택 | - |
dc.contributor.AlternativeAuthor | 정진행 | - |
dc.identifier.doi | 10.1097/JTO.0b013e3181d5e554 | - |
dc.citation.journaltitle | JOURNAL OF THORACIC ONCOLOGY | - |
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