S-Space College of Medicine/School of Medicine (의과대학/대학원) Pathology (병리학전공) Journal Papers (저널논문_병리학전공)
Sequential evolution of IL-17 responses in the early period of allograft rejection
- Min, Sang Il; Ha, Jongwon; Park, Chung-Gyu; Won, Jae Kyung; Min, Seung-Kee; Kim, Sang Joon; Park, Yang Jin
- Issue Date
- EXPERIMENTAL AND MOLECULAR MEDICINE; Vol.41 10; 707-716
- In addition to CD4(+)CD25(+)Foxp3(+) regulatory T (T(reg)) cells which protect against autoimmune tissue injury, IL-17-producing CD4(+)T (T(h)17) cells have been recently described and shown to play a crucial role in autoimmune injury. It appears that there is a reciprocal developmental pathway between T(h)17 and T(reg) cells. Although IL-17 is known to be associated with allograft rejection, the cellular source of IL-17 and the nature of T(h)17 in the context of allograft rejection remain unknown. In the current study, the dynamics of T(reg) and IL-17-producing cells after syngeneic and allogeneic transplantation were examined using a wild-type murine cardiac transplantation model. Ly6G(+) cells were found to produce IL-17 during the early postoperative period and CD8(+) as well as CD4(+)T cells were also found to produce IL-17 during alloimmune response. Graft-infiltrating Ly6G(+), CD4(+), and even CD8(+) cells were found to express IL-17 highly compared to those in spleen. Although the frequencies of T(h)17 and T(reg) were found to gradually increase in both syngeneic and allogeneic recipients, T(h)17/T(reg) ratios were significantly higher in recipients with allograft rejection than in syngeneic recipients. In conclusion, IL-17 is produced by neutrophils during the early postoperative period and subsequently by T(h)17 and CD8(+) T cells during allograft rejection. T(h)17/T(reg) imbalance is associated with the development of allograft rejection. This study would provide basic information on T(h)17 biology for future investigation in the field of transplantation.