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Follicular dendritic cell sarcoma with immature T-cell proliferation

Cited 28 time in Web of Science Cited 24 time in Scopus
Authors
Kim, Wook Youn; Kim, Haeryoung; Jeon, Yoon Kyung; Kim, Chul-Woo
Issue Date
2010-01
Publisher
W B SAUNDERS CO-ELSEVIER INC
Citation
HUMAN PATHOLOGY; Vol.41 1; 129-133
Keywords
Follicular dendritic cell sarcomaImmature T cellsPemphigusMyasthenia gravis
Abstract
Follicular dendritic cell sarcoma is characterized by proliferation of spindled to ovoid cells reminiscent of follicular dendritic cells. However, the association of follicular dendritic cell sarcoma with a dense infiltration of immature T cells has not hitherto been reported. We report an unusual case of follicular dendritic cell sarcoma of the mesentery with immature T-cell proliferation in a 68-year-old man. The infiltrating immature T cells demonstrated expression of CD3, CD1a, TdT, and coexpression of CD4 and CD8 by immunohistochemistry. In addition, the patient was subsequently diagnosed with myasthenia gravis and paraneoplastic pemphigus and died of distant metastasis within 2 years after initial diagnosis of follicular dendritic cell sarcoma. The aggressive clinical course of this case contrasts with the indolent course of follicular dendritic cell sarcomas, and thus, the prognostic implications of follicular dendritic cell sarcoma with immature T-cell proliferation require clarification. The complication of myasthenia gravis and paraneoplastic pemphigus may suggest that immature T-cell proliferation has an autoimmunity-related systemic influence. (c) 2010 Elsevier Inc. All rights reserved.
ISSN
0046-8177
Language
English
URI
http://hdl.handle.net/10371/76718
DOI
https://doi.org/10.1016/j.humpath.2009.05.014
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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