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Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with advanced stage endometriosis

Cited 16 time in Web of Science Cited 13 time in Scopus
Authors
Kim, Hoon; Ku, Seung Yup; Kim, Sung Hoon; Lee, Gyoung Hoon; Kim, Jong Mee; Moon, Shin Yong; Lee, Taek Hoo; Choi, Young Min
Issue Date
2009-10
Publisher
OXFORD UNIV PRESS
Citation
HUMAN REPRODUCTION; Vol.24 10; 2656-2659
Keywords
endometriosispolymorphismeNOSNOS3
Abstract
Altered expression of endothelial nitric oxide synthase (eNOS) has been reported to be involved in the development of endometriosis. The genotypes of eNOS gene (NOS3) may be responsible for variation in its enzymatic activity as well as plasma concentration of nitric oxide. The Glu298Asp polymorphism of the NOS3 may modulate angiogenesis and influence individual susceptibility to endometriosis. This study was designed to evaluate the association between the Glu298Asp polymorphism of the NOS3 and advanced stage endometriosis. This study consisted of 299 women with advanced stage endometriosis and 459 control women without endometriosis in a Korean population. Genotyping results of the Glu298Asp polymorphism of the NOS3 were analyzed between the endometriosis and control group. The genotypic frequencies were significantly different between women with and without endometriosis. The frequency of the non-GG genotype (GT + TT) was higher in the endometriosis group than in the control group (P = 0.001). These findings suggest that the T allele, encoding aspartic acid, of the Glu298Asp polymorphism of the NOS3 may be associated with advanced stage endometriosis in the Korean population.
ISSN
0268-1161
Language
English
URI
http://hdl.handle.net/10371/76743
DOI
https://doi.org/10.1093/humrep/dep212
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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