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Human papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment

Cited 37 time in Web of Science Cited 41 time in Scopus
Authors
Kim, Mi-Kyung; Kim, Hee Seung; Oh, Jung-Min; Kim, Su-Hyeong; Juhnn, Yong-Sung; Song, Yong-Sang; Lim, Jeong Mook; Han, Jae Yong
Issue Date
2010-12-15
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOCHEMICAL PHARMACOLOGY; Vol.80 12; 1930-1935
Keywords
Human papillomavirusCOX-2Cervical cancerEGFRE5
Abstract
Human papillomavirus (HPV) infection is considered to be the necessary cause of cervical cancer. E6 and E7 oncoproteins of HPV have been known to play major roles in malignant transformation of cervical cells, inhibiting the tumor suppressors p53 and Rb. However, the role of E5 oncoprotein has been relatively less defined. HPV 16 E5 is a hydrophobic membrane-bound protein which associates with the Golgi apparatus, endoplasmic reticulum and perinuclear membrane. Accumulating evidences have suggested that E5 oncoprotein may also contribute to cervical carcinogenesis through modulating cellular signaling pathways in addition to augmenting the immortalization potential of E6 and E7. Multiple mechanisms, including activation of EGFR or inflammatory cell signaling pathway, have been implicated in malignant transformation by HPV 16 E5. Therefore, targeting E5 may be a rational approach for chemoprevention and treatment of cervical cancer, and understanding its oncogenic processes may help us to design novel therapeutic strategies. In this review, we discussed the roles of HPV 16 E5 in cervical carcinogenesis, altering several cellular signaling pathways involved in cell proliferation, angiogenesis and apoptosis. (C) 2010 Elsevier Inc. All rights reserved.
ISSN
0006-2952
Language
English
URI
http://hdl.handle.net/10371/76778
DOI
https://doi.org/10.1016/j.bcp.2010.07.013
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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