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Use of Hormonal Protection for Chemotherapy-induced Gonadotoxicity

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dc.contributor.authorKim, S. Samuel-
dc.contributor.authorLee, Jung Ryeol-
dc.contributor.authorJee, Byung Chul-
dc.contributor.authorSuh, Chang Suk-
dc.contributor.authorTing, Alison-
dc.contributor.authorPetroff, Brian-
dc.contributor.authorKim, Seok Hyun-
dc.date.accessioned2012-06-04T06:13:14Z-
dc.date.available2012-06-04T06:13:14Z-
dc.date.issued2010-12-
dc.identifier.citationCLINICAL OBSTETRICS AND GYNECOLOGY; Vol.53 4; 740-752ko_KR
dc.identifier.issn0009-9201-
dc.identifier.urihttp://hdl.handle.net/10371/76789-
dc.description.abstractIt is still controversial that GnRH agonist (GnRHa) protects ovarian function from chemotherapy-induced gonadotoxicity. Indeed, the results of many studies related to this issue are neither consistent nor convincing because of the weak study design and the inadequate sample size. We identified 11 prospective controlled studies (8 nonrandomized and 3 randomized) for the systemic review and meta-analysis. The meta-analysis showed that GnRHa cotreatment during chemotherapy can protect ovarian function. However, it is worthy to note that the result of this meta-analysis is influenced by nonrandomized studies. The protective effect of GnRHa will remain elusive until the currently ongoing large, prospective, randomized studies are completed. In addition, tamoxifen, a selective estrogen receptor modulator, may have the protective effect against loss of follicles and ovarian function, which was caused by chemotherapy.ko_KR
dc.language.isoenko_KR
dc.publisherLIPPINCOTT WILLIAMS & WILKINSko_KR
dc.subjectfertility preservationko_KR
dc.subjectGnRH agonistko_KR
dc.subjecttamoxifenko_KR
dc.subjectchemotherapyko_KR
dc.subjectcancerko_KR
dc.subjectgonadotoxicityko_KR
dc.titleUse of Hormonal Protection for Chemotherapy-induced Gonadotoxicityko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이정렬-
dc.contributor.AlternativeAuthor조병철-
dc.contributor.AlternativeAuthor서창석-
dc.contributor.AlternativeAuthor김석현-
dc.identifier.doi10.1097/GRF.0b013e3181f96cb1-
dc.citation.journaltitleCLINICAL OBSTETRICS AND GYNECOLOGY-
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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