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Role of Systematic Lymphadenectomy and Adjuvant Radiation in Early-Stage Endometrioid Uterine Cancer

Cited 11 time in Web of Science Cited 11 time in Scopus
Authors

Jeong, Nan-Hee; Lee, Jong-Min; Lee, Jae-Kwan; Kim, Mi-Kyung; Cho, Chi-Heum; Park, Sang-Yoon; Kim, Ki-Tae; Park, Chan-Yong; Kim, Seok-Mo; Kim, Young-Jae

Issue Date
2010-11
Publisher
SPRINGER
Citation
ANNALS OF SURGICAL ONCOLOGY; Vol.17 11; 2951-2957
Abstract
Objective. To determine the roles of lymphadenectomy in endometrioid uterine cancer patients and adjuvant radiation in early-stage endometrioid uterine cancer patients who underwent systematic lymphadenectomy. Methods. A retrospective analysis of 758 patients surgically treated for early-stage endometrioid uterine cancer from 2000 to 2006 was conducted. The primary outcome was 5-year overall survival in relation to systematic lymphadenectomy with or without adjuvant radiation. Results. Of the 758 patients, 547 (72.2%) underwent complete surgical staging, including systematic lymphadenectomy; adjuvant radiation was administered to 207 patients (27.3%). Within median follow-up of 35 months, systematic lymphadenectomy did not affect overall survival in early-stage patients (P = 0.4480). In the high-risk, early-stage group, however, the 5-year survival rate of the systematic lymphadenectomy group showed better survival compared with the no systematic lymphadenectomy group (P = 0.0095). Also, adjuvant radiation did not affect overall survival in early-stage patients (P = 0.1170), even in the group of high-risk, early-stage patients (P = 0.5680) who underwent systematic lymphadenectomy. Conclusions. Systematic lymphadenectomy provided a survival benefit in high-risk endometrioid uterine cancer patients. However, in patients who underwent systematic lymphadenectomy, adjuvant radiation was not beneficial, even in high-risk patients.
ISSN
1068-9265
Language
English
URI
https://hdl.handle.net/10371/76800
DOI
https://doi.org/10.1245/s10434-010-1169-y
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