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Oxidized Low-Density Lipoprotein and Oxidative Stress in the Development of Glomerulosclerosis

Cited 30 time in Web of Science Cited 35 time in Scopus
Authors
Lee, Hyun Soon; Song, Chi Young
Issue Date
2009
Publisher
KARGER
Citation
AMERICAN JOURNAL OF NEPHROLOGY; Vol.29 1; 62-70
Keywords
Angiotensin IITGF-beta signalingReactive aldehydesNADPH oxidaseDyslipidemiaMesangial matrix
Abstract
Glomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed. Copyright (C) 2008 S. Karger AG, Basel
ISSN
0250-8095
Language
English
URI
http://hdl.handle.net/10371/76802
DOI
https://doi.org/10.1159/000151277
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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