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Oxidized Low-Density Lipoprotein and Oxidative Stress in the Development of Glomerulosclerosis
Cited 38 time in
Web of Science
Cited 41 time in Scopus
- Authors
- Issue Date
- 2009
- Publisher
- KARGER
- Citation
- AMERICAN JOURNAL OF NEPHROLOGY; Vol.29 1; 62-70
- Keywords
- Angiotensin II ; TGF-beta signaling ; Reactive aldehydes ; NADPH oxidase ; Dyslipidemia ; Mesangial matrix
- Abstract
- Glomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed. Copyright (C) 2008 S. Karger AG, Basel
- ISSN
- 0250-8095
- Language
- English
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