S-Space College of Medicine/School of Medicine (의과대학/대학원) Pathology (병리학전공) Journal Papers (저널논문_병리학전공)
Oxidized Low-Density Lipoprotein and Oxidative Stress in the Development of Glomerulosclerosis
- Lee, Hyun Soon; Song, Chi Young
- Issue Date
- AMERICAN JOURNAL OF NEPHROLOGY; Vol.29 1; 62-70
- Angiotensin II; TGF-beta signaling; Reactive aldehydes; NADPH oxidase; Dyslipidemia; Mesangial matrix
- Glomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed. Copyright (C) 2008 S. Karger AG, Basel
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