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Ectopic pregnancy after assisted reproductive technology: what are the risk factors?

Cited 43 time in Web of Science Cited 49 time in Scopus
Authors
Chang, Hye Jin; Suh, Chang Suk
Issue Date
2010-06
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY; Vol.22 3; 202-207
Keywords
assisted reproductive technologyrisk factorectopic pregnancyIVF and embryo transfer
Abstract
Purpose of review This review discusses recent publications that investigate risk factors associated with ectopic pregnancy after IVF. Recent findings Data on the risk factors for developing ectopic pregnancy after IVF are still inconsistent. Between fresh nondonor IVF and embryo transfer cycles, the significant risk factor for ectopic pregnancy was tubal factor infertility, and endometriosis, rather than male factor infertility. Higher ectopic pregnancy rate could be associated with zygote intrafallopian transfer, assisted hatching, large embryo transfer volume, deep fundal transfer, and frozen embryo transfer. The supraphysiologic progesterone level may decrease uterine contractility and enhance implantation in the uterine cavity in fresh embryo transfer compared with frozen embryo transfer cycles. Although recent results suggest reassurance in risk of ectopic pregnancy with frozen transfer, clinicians should be remembering this possibility while performing a frozen embryo transfer. Higher implantation potential per embryo at the blastocyst stage may increase the risk of ectopic pregnancy than cleavage stage. Especially, according to numbers of embryos transferred, different risk of ectopic pregnancy after IVF was noted. Summary Different hormonal milieu, the reproductive health characteristics of infertile women such as distorted tubal function, technical issues of IVF procedures, and the estimated embryo implantation potential are possible risk factors. How each factor contributes to the risk of occurring ectopic pregnancy after assisted reproductive technology is uncertain and needs further investigation.
ISSN
1040-872X
Language
English
URI
http://hdl.handle.net/10371/76812
DOI
https://doi.org/10.1097/GCO.0b013e32833848fd
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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