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Administration of Intravenous Albumin around the Time of Oocyte Retrieval Reduces Pregnancy Rate without Preventing Ovarian Hyperstimulation Syndrome: A Systematic Review and Meta-Analysis

Cited 11 time in Web of Science Cited 14 time in Scopus
Authors
Jee, Byung Chul; Suh, Chang Suk; Kim, Yong Beom; Kim, Seok Hyun; Kim, Jung Gu; Moon, Shin Yong; Choi, Young Min
Issue Date
2010
Publisher
KARGER
Citation
GYNECOLOGIC AND OBSTETRIC INVESTIGATION; Vol.70 1; 47-54
Keywords
Intravenous albuminMeta-analysisHydroxyethyl starchOvarian hyperstimulation syndromePregnancy
Abstract
Background/Aim: The aim of this meta-analysis was to evaluate whether IV albumin infusion around the time of oocyte retrieval prevents ovarian hyperstimulation syndrome (OHSS) and affects the pregnancy rate. Methods: A meta-analysis of data from 9 randomized controlled trials including 1,613 women at high risk for developing OHSS in in vitro fertilization cycles was performed. Results: The combined incidence of severe OHSS was 6.0% in the IV albumin group and 7.9% in saline or no treatment groups. These rates were statistically not different (RR = 0.80, 95% Cl = 0.57-1.12). Treatment with IV albumin significantly lowered the pregnancy rates (RR = 0.85, 95% Cl = 0.74-0.98). Conclusions: The combined data presented in this meta-analysis do not support a benefit for IV albumin around the time of oocyte retrieval in preventing OHSS and even showed a deleterious effect on the pregnancy rate. Copyright (C) 2010 S. Karger AG, Basel
ISSN
0378-7346
Language
English
URI
http://hdl.handle.net/10371/76833
DOI
https://doi.org/10.1159/000286379
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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