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Caveolae-mediated entry of Salmonella typhimurium into senescent nonphagocytotic host cells
Cited 27 time in
Web of Science
Cited 27 time in Scopus
- Authors
- Issue Date
- 2010-04
- Publisher
- WILEY-BLACKWELL PUBLISHING, INC
- Citation
- AGING CELL; Vol.9 2; 243-251
- Keywords
- senescence ; infection ; endocytosis ; S. typhimurium ; caveolae ; caveolin-1
- Abstract
- Elderly individuals have an increased susceptibility to microbial infections because of age-related anatomical, physiological, and environmental factors. However, the mechanism of aging-dependent susceptibility to infection is not fully understood. Here, we found that caveolae-dependent endocytosis is elevated in senescent cells. Thus, we focused on the implications of caveolae-dependent endocytosis using Salmonella typhimurium, which causes a variety of diseases in humans and animals by invading the eukaryotic host cell. Salmonella invasion increased in nonphagocytotic senescent host cells in which caveolin-1 was also increased. When caveolae structures were disrupted by methyl-beta-cyclodextrin or siRNA of caveolin-1 in the senescent cells, Salmonellae invasion was reduced markedly compared to that in nonsenescent cells. In contrast, the over-expression of caveolin-1 led to increased Salmonellae invasion in nonsenescent cells. Moreover, in aged mice, caveolin-1 was found to be highly expressed in Peyer`s patch and spleen, which are targets for infection by Salmonellae. These results suggest that high levels of caveolae and caveolin-1 in senescent host cells might be related to the increased susceptibility of elderly individuals to microbial infections.
- ISSN
- 1474-9718
- Language
- English
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