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Caveolae-mediated entry of Salmonella typhimurium into senescent nonphagocytotic host cells

Cited 20 time in Web of Science Cited 21 time in Scopus
Authors
Lim, Jae Sung; Choy, Hyon E.; Park, Sang Chul; Han, Jung Min; Cho, Kyung A.; Jang, Ik-Soon
Issue Date
2010-04
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
AGING CELL; Vol.9 2; 243-251
Keywords
senescenceinfectionendocytosisS. typhimuriumcaveolaecaveolin-1
Abstract
Elderly individuals have an increased susceptibility to microbial infections because of age-related anatomical, physiological, and environmental factors. However, the mechanism of aging-dependent susceptibility to infection is not fully understood. Here, we found that caveolae-dependent endocytosis is elevated in senescent cells. Thus, we focused on the implications of caveolae-dependent endocytosis using Salmonella typhimurium, which causes a variety of diseases in humans and animals by invading the eukaryotic host cell. Salmonella invasion increased in nonphagocytotic senescent host cells in which caveolin-1 was also increased. When caveolae structures were disrupted by methyl-beta-cyclodextrin or siRNA of caveolin-1 in the senescent cells, Salmonellae invasion was reduced markedly compared to that in nonsenescent cells. In contrast, the over-expression of caveolin-1 led to increased Salmonellae invasion in nonsenescent cells. Moreover, in aged mice, caveolin-1 was found to be highly expressed in Peyer`s patch and spleen, which are targets for infection by Salmonellae. These results suggest that high levels of caveolae and caveolin-1 in senescent host cells might be related to the increased susceptibility of elderly individuals to microbial infections.
ISSN
1474-9718
Language
English
URI
http://hdl.handle.net/10371/76849
DOI
https://doi.org/10.1111/j.1474-9726.2010.00554.x
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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