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Phthalates Exposure and Attention-Deficit/Hyperactivity Disorder in School-Age Children

Cited 143 time in Web of Science Cited 152 time in Scopus
Authors
Kim, Bung-Nyun; Cho, Soo-Churl; Kim, Yeni; Shin, Min-Sup; Kim, Jae-Won; Kim, Hyo-Won; Hong, Yun-Chul; Bhang, Soo-Young; Yang, Young Hee; Yoo, Hee-Jeong
Issue Date
2009-11-15
Publisher
ELSEVIER SCIENCE INC
Citation
BIOLOGICAL PSYCHIATRY; Vol.66 10; 958-963
Keywords
ADHDphthalateneuropsychology
Abstract
Background: Very few studies have examined the association between attention-deficit/hyperactivity disorder (ADHD) and phthalate exposure in humans. The aim of this study was to investigate the impact of phthalates on symptoms of ADHD in school-age children. Methods: A cross-sectional examination of urine phthalate concentrations was performed, and scores on measures of ADHD symptoms and neuropsychological dysfunction with regard to attention and impulsivity were obtained from 261 Korean children, age 8-11 years. Results: Mono-2-ethylheyl phthalate (MEHP) and mono-2-ethyl-5-oxohexylphthalate (MEOP) for metabolites of Di-2-ethylhexylphthalate (DEHP) and mono-n-butyl phthalate (MNBP) for metabolites of dibutyl phthalate (DBP) were measured in urine samples. The mean concentrations of MEHP, MEOP, and MNBP were 34.0 mu g/dL (SD = 36.3; range: 2.1-386.7),23.4 mu g/dL (SD = 23.0; range:.75-244.8), and 46.7 mu g/L (SD = 21.4; range: 13.2-159.3), respectively. After adjustment for covariates, teacher-rated ADHD scores were significantly associated with DEHP metabolites but not with DBP metabolites. We also found significant relationships between the urine concentrations of metabolites for DBP and the number of omission and commission errors in continuous performance tests (CPT) after adjustment for covariates. Conclusion: The present study showed a strong positive association between phthalate metabolites in urine and symptoms of ADHD among school-age children.
ISSN
0006-3223
Language
English
URI
http://hdl.handle.net/10371/76874
DOI
https://doi.org/10.1016/j.biopsych.2009.07.034
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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