Browse

International Lung Cancer Consortium: Coordinated association study of 10 potential lung cancer susceptibility variants

Cited 40 time in Web of Science Cited 45 time in Scopus
Authors
Truong, Therese; Sauter, Wiebke; McKay, James D.; Hosgood, H. Dean, III; Amos, Christopher I.; Muscat, Joshua; Illig, Thomas; Bickeboeller, Heike; Dienemann, Hendrik; Duell, Eric J.; Kim, Jin Hee; Hong, Yun-Chul; Le Marchand, Loic; Haugen, Aage; Zienolddiny, Shanbeh; Yang, Ping; Naeim, Behnaz Pezeshki; Zhang, Zuo-Feng; Janout, Vladimir; Foretova, Lenka; Bencko, Vladimir; Constantinescu, Vali; Fabianova, Eleonora; Rudnai, Peter; Lissowska, Jolanta; Szeszenia-Dabrowska, Neonilia; Zaridze, David; Hung, Rayjean J.; Brennan, Paul; Boffetta, Paolo; Chabrier, Amelie; Wang, Ying; Lubinski, Jan; Lener, Marcin; Trubicka, Joanna; Landi, Maria Teresa; Thun, Michael; Albanes, Demetrius; Caporaso, Neil E.; Lan, Qing; Ng, Daniel P. K.; Seow, Adeline; Suzuki, Takeshi; Matsuo, Keitaro; Shen, Hongbing; Kiyohara, Chikako; Andrew, Angeline S.; Risch, Angela; Wichmann, H. Erich; Lazarus, Philip; Spitz, Margaret; Gallagher, Carla
Issue Date
2010-04
Publisher
OXFORD UNIV PRESS
Citation
CARCINOGENESIS; Vol.31 4; 625-633
Abstract
Background. Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected because of their prior evidence of an association with lung cancer. These variants belonged to candidate genes from different cancer-related pathways including inflammation (IL1B), folate metabolism (MTHFR), regulatory function (AKAP9 and CAMKK1), cell adhesion (SEZL6) and apoptosis (FAS, FASL, TP53, TP53BP1 and BAT3). Methods. Genotype data from 15 ILCCO case-control studies were available for a total of 8431 lung cancer cases and 11 072 controls of European descent and Asian ethnic groups. Unconditional logistic regression was used to model the association between each variant and lung cancer risk. Results. Only the association between a non-synonymous variant of TP53BP1 (rs560191) and lung cancer risk was significant (OR = 0.91, P = 0.002). This association was more striking for squamous cell carcinoma (OR = 0.86, P = 6 x 10(-4)). No heterogeneity by center, ethnicity, smoking status, age group or sex was observed. In order to confirm this association, we included results for this variant from a set of independent studies (9966 cases/11 722 controls) and we reported similar results. When combining all these studies together, we reported an overall OR = 0.93 (0.89-0.97) (P = 0.001). This association was significant only for squamous cell carcinoma [OR = 0.89 (0.85-0.95), P = 1 x 10(-4)]. Conclusion. This study suggests that rs560191 is associated to lung cancer risk and further highlights the value of consortia in replicating or refuting published genetic associations.
ISSN
0143-3334
Language
English
URI
http://hdl.handle.net/10371/76884
DOI
https://doi.org/10.1093/carcin/bgq001
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse